Alveolar-capillary Reserve After Exercise in Chronic Obstructive Pulmonary Disease (COPD) (COP-DTPA)

NCT ID: NCT06287476

Last Updated: 2025-12-08

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 32 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-05-06
• Study Completion Date: 2025-05-02

Brief Summary

It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass.

Detailed Description

It is unknown whether individuals with COPD exhibit abnormal alveolar-capillary breaching during exercise, and whether this contributes to exertional dyspnoea. The aim of this study is to investigate whether individuals with COPD exhibit an abnormal increase in alveolar-capillary breaching during exertion, as indicated by an increase alveolar-capillary permeability with a concomitantly exacerbated increase in lung tissue mass. The study participants include a control group and a group with COPD (GOLD I-III). Participants are undergoing three study days: (1) Measurement of maximal aerobic capacity and lung function test, (2) lung tissue mass and alveolar-capillary permeability is measured at rest and again 2 hours later, immediately after the participant has exercised on a bicycle ergometer and (3) supine cardiac output and pulmonary capillary blood volume will be measured at rest and immediately after exercise.

Conditions

Chronic Obstructive Pulmonary Disease

Study Design

• Allocation Method: NON_RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Control Group

This arm consist of only healthy participants (age (+/- 3 years) and sex matched to the COPD group), which will undergo three study visits

Group Type: EXPERIMENTAL

Acute exercise bout on visit 2 and 3

Intervention Type: OTHER

1\) a 5-minute warm-up, 2) 4 minutes at 60% of the maximal workload (determined on Study Day 1), 3) 2 minutes active break at 15 watt, 4) 4 minutes at maximal workload.

COPD group

This arm consist of only COPD patients, which will undergo three study visits

Group Type: EXPERIMENTAL

Acute exercise bout on visit 2 and 3

Intervention Type: OTHER

1\) a 5-minute warm-up, 2) 4 minutes at 60% of the maximal workload (determined on Study Day 1), 3) 2 minutes active break at 15 watt, 4) 4 minutes at maximal workload.

Interventions

Acute exercise bout on visit 2 and 3

1\) a 5-minute warm-up, 2) 4 minutes at 60% of the maximal workload (determined on Study Day 1), 3) 2 minutes active break at 15 watt, 4) 4 minutes at maximal workload.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Men and women
• 45-80 years old
• COPD (GOLD stage I to III)
• Resting arterial oxygenation > 90%

• Men and women
• 45-80 years old
• Non-smokers
• Normal lung function
• Same sex, age (± 3 years) as the COPD group

Exclusion Criteria

• Symptoms of ischemic heart disease
• Known heart failure
• Symptoms of illness, including fever, within 2 weeks prior to the study
• Pregnancy
• • Known renal or liver diseaseActive smoking (within 3 weeks)

• Known chronic lung disease
• Symptoms of ischemic heart disease
• Known heart failure
• Symptoms of illness, including fever, within 2 weeks prior to the study
• Pregnancy
• Known renal or liver disease
• Active smoking (within 3 weeks)

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Rigshospitalet, Denmark

OTHER

Sponsor Role: lead

Responsible Party

Ronan Berg

MD, DMSc, Associate Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Center For Physical Activity Research, Rigshospitalet

Copenhagen, , Denmark

Countries

Denmark

Other Identifiers

H-23043870

Identifier Type: -

Identifier Source: org_study_id