Ultrasound Assessment of Rectus Femoris Cross-sectionnal Area Following Lung Transplantation

NCT ID: NCT06268171

Last Updated: 2025-09-12

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 42 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-03-27
• Study Completion Date: 2025-05-27

Brief Summary

In France, the profile of patients receiving lung transplants has changed in recent years, mainly due to the advent of treatment for cystic fibrosis. This progress has led to an evolution in the patient profile, with an increase in cases of pulmonary fibrosis or COPD, and an increase in the average age of patients. In these older patients, sarcopenia, a condition characterized by loss of muscle mass, is a major concern, as it exacerbates morbidity and mortality.

After transplantation, patients are at risk of developing neuromyopathy due to their hospitalization in intensive care. There is currently no effective preventive treatment for this condition, underlining the need for early rehabilitation strategies. The combination of sarcopenia and neuromyopathy diminishes their functional capabilities on discharge from the ICU.

Muscle ultrasound, a simple, non-invasive technique, is already used to assess muscle function in intensive care patients. This study aims to evaluate the use of ultrasound to measure muscle loss in lung transplant patients, in particular by examining the rectus femoris muscle. Objectives include observing variations in the surface area of the rectus femoris muscle before and after transplantation, identifying factors influencing this variation, and exploring its relationship with post-transplant morbidity.

In summary, this study seeks to better understand muscle loss in lung transplant patients using ultrasound, in order to identify risk factors and guide the development of post-transplant rehabilitation strategies.

Conditions

Lung Transplant; Physiotherapy; Sarcopenia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: PROSPECTIVE

Study Groups

Study group

transplant patients with ultrasound measurement of the cross-sectional area of the rectus femoris

ultrasound measurement of the cross-sectional area of the rectus femoris

Intervention Type: OTHER

ultrasound measurement of the cross-sectional area of the rectus femoris at D-1 and D+3, +7 , +14

Interventions

ultrasound measurement of the cross-sectional area of the rectus femoris

ultrasound measurement of the cross-sectional area of the rectus femoris at D-1 and D+3, +7 , +14

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Patient over the age of 18
• Patient registered on the lung transplant list at Hôpital Foch for a single or double-lung transplant
• Patient who did not object to inclusion in the study
• Patient affiliated to a French health insurance plan

Exclusion Criteria

• Patient listed for a combined transplant (heart-lung, liver-lung, lung-kidney)
• Patient on national priority list (super-emergency)
• Pregnant or breast-feeding patient
• Patient under guardianship

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hopital Foch

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Matthieu Reffienna

Role: PRINCIPAL_INVESTIGATOR

Hopital Foch

Locations

Hopital Foch

Suresnes, Hauts de seine, France

Countries

France

Other Identifiers

2023-A02390-45

Identifier Type: OTHER

Identifier Source: secondary_id

2023_0214

Identifier Type: -

Identifier Source: org_study_id