Dynamics of AMR Spread, Persistence and Evolution Between Humans, Animals and Their Environment
NCT ID: NCT06262009
Last Updated: 2024-02-15
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
525 participants
OBSERVATIONAL
2024-09-30
2027-03-31
Brief Summary
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Detailed Description
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There is a great concern that humans in contact with animals be at risk of ESC-E/CP-E acquisition. Whereas an increase in ESC-E carriage in farmers in contact with their food-producing animals was reported, AMR transmission to humans through direct contacts with companion animals has been much less studied. Owing the close relationships between pets and owners, and the fact that 50% of households host a dog or a cat in France, the hypothesis of pet ownership being a risk for humans to acquire ESC-E/CP-E appears strongly relevant. The DYASPEO project will investigate this question through a combination of several approaches from field to laboratory studies, and including epidemiology, ecology, molecular and population genomics, studies on intestinal microbiota, modelling and social sciences.
We hypothesize that the interface between humans and companion animals plays a significant role in the transfer of ESC-E/CP-E. This hypothesis is corroborated (i) by recent data in France showing that antibiotic exposure of companion animals is still increasing contrary to all other animal host (e.g. food-producing animals) and (ii) by a recent study from the consortium demonstrating a high AMR prevalence in dogs getting back home after hospitalization.
Conditions
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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household
House Members (adults and minors) from 175 households owning a dog
human faecal collection
collecting stools 6 times over a 90 days period and complete a questionnaire at the same times: D1, D7, D15, D30, D60 and D90
ancillary study
interviews and/or ethnographic observations for 50 volunteers
Interventions
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human faecal collection
collecting stools 6 times over a 90 days period and complete a questionnaire at the same times: D1, D7, D15, D30, D60 and D90
ancillary study
interviews and/or ethnographic observations for 50 volunteers
Eligibility Criteria
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Inclusion Criteria
* Planning to live in the same habitat in the next three months following inclusion (except for holidays).
* Written consent of all adults and of at least one of the two parents for minors under parental authority. A different information note will be elaborated for each age category (6-10 yr-old, 10-15 yr-old and 16-18 yr-old).
* Owning a dog recorded for a surgery at the National Veterinary School
Exclusion Criteria
* Subject in alternating custody
* Subject under legal protection (guardianship)
* Subject deprived of liberty under judicial constraint
* Subject undergoing psychiatric care
* Lack of affiliation to a social security scheme
* Volunteers who do not speak/write French
ALL
Yes
Sponsors
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Assistance Publique - Hôpitaux de Paris
OTHER
Responsible Party
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Principal Investigators
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Jean-Yves Madec, PHD
Role: PRINCIPAL_INVESTIGATOR
ANSES
Locations
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the National Veterinary School Alfort
Maisons-Alfort, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2023-A02282-43
Identifier Type: OTHER
Identifier Source: secondary_id
APHP220101
Identifier Type: -
Identifier Source: org_study_id
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