Improving the Quality of Cryopreserved Ovarian Tissue Reimplantation Using Platelet-enriched Autologous Plasma

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-03-01

Study Completion Date

2033-12-29

Brief Summary

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The study is aimed to evaluate the effects of intraovarian injection of autologous Platelet-enriched Autologous Plasma on the outcomes of orthotopic transplantation of cryopreserved ovarian tissue.

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Detailed Description

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Conditions

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Cryopreservation Ovary Injury Infertility, Female Menopause Ovarian Failure

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Study group

Cryopreserved Ovarian Tissue Reimplantation Using Platelet-enriched Autologous Plasma

Group Type EXPERIMENTAL

Cryopreserved Ovarian Tissue Reimplantation

Intervention Type PROCEDURE

Cryopreserved Ovarian Tissue Reimplantation Using Platelet-enriched Autologous Plasma

Interventions

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Cryopreserved Ovarian Tissue Reimplantation

Cryopreserved Ovarian Tissue Reimplantation Using Platelet-enriched Autologous Plasma

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* request for cryopreserved ovarian tissue transplantation;
* premature ovarian failure or irregular mentrual cycles;
* negative test for HIV, HBV, HCV, Treponema pallidum;
* negative PAP test;
* oncological authorization;
* absence of neoplastic contamination in the cryopreserved ovarian tissue;
* Informed consent

Exclusion Criteria

* neoplastic contamination in cryopreserved ovarian tissue;
* history of endometriosis;
* endocrinological disorders present and not treated (uncompensated thyroid dysfunction, diabetes (type 1, type 2);
* body mass index (BMI) \>30 kg/m2;
* circulating platelet level \< 150,000 / mml;
* bacterial infection;
* ongoing use of anticoagulants;
* bleeding diathesis.

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No