Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
92 participants
INTERVENTIONAL
2019-10-24
2026-12-31
Brief Summary
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The 2 conservatives techniques used are:
1. The combined technique
2. CO2 laser vaporization only
Ovarian reserve will be assessed by consecutive measurements of AMH serum levels before and after surgery.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
NONE
Study Groups
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The combined technique
First step consisting of stripping the cyst wall for 80% of the surface, followed by a second step consisting of ablation of the remaining 20% cyst surface.
Comparison between 2 different laparoscopic techniques in conservative surgical treatment of endometriomas (both arms are existing and accepted surgical strategies).
cf. different arms
CO2 laser vaporization only
CO2 laser vaporization only of the complete inner cystic wall after drainage of the cyst content, irrigation and inspection of its inner wall. Ablation of the inner cyst wall using the CO2 laser (Lumenis). Power settings of 30-55W for CO2 laser beam and 6-10W for CO2 fibre are used. The laser should be on the ablate function to widen the beam (e.g. Surgitouch modus). The laser should be applied in Surgitouch modus so that it can ablate the cyst surface while preserving the underlying healthy tissue.
Comparison between 2 different laparoscopic techniques in conservative surgical treatment of endometriomas (both arms are existing and accepted surgical strategies).
cf. different arms
Interventions
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Comparison between 2 different laparoscopic techniques in conservative surgical treatment of endometriomas (both arms are existing and accepted surgical strategies).
cf. different arms
Eligibility Criteria
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Inclusion Criteria
* Unilateral endometriotic cysts with a mean diameter of \>=2.5cm and ≤8 cm, measured in 3 dimensions.
* Presence of a contralateral endometrioma of ≤ 2cm is allowed
* Complaining of infertility and/or pain
* BMI ≤35
* Use of contraception (combined or Progesteron only) for at least 4 weeks before surgery
Exclusion Criteria
* Contra-indication for the use of contraception (combined or Progesteron only)
* Use of GnRH analogues preoperatively and in the first 3 months postoperatively
* (History of) hysterectomy
* Prior unilateral oophorectomy
* Pituitary/hypothalamic disorders
* Suspected malignancy
* Contralateral endometrioma of \>2 cm
* AMH \<0.7 preoperatively
* Pregnancy
18 Years
40 Years
FEMALE
No
Sponsors
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GZA Ziekenhuizen Campus Sint-Augustinus
OTHER
Centre Hospitalier Régional de la Citadelle
OTHER
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
OTHER
Universitaire Ziekenhuizen KU Leuven
OTHER
Responsible Party
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Principal Investigators
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Carla Tomassetti, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Leuven University Fertility Center
Locations
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GZA Sint-Augustinus
Antwerp, , Belgium
Cliniques universitaires Saint-LUC (UCL)
Brussels, , Belgium
UZLeuven
Leuven, , Belgium
CHR La Citadelle
Liège, , Belgium
Countries
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Central Contacts
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Facility Contacts
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Brecht Geysenbergh, MD
Role: primary
Laurence Beausaert
Role: primary
Celine Bafort, MD
Role: primary
Marie Timmermans, Msc
Role: primary
References
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Bafort C, Lie Fong S, Fieuws S, Geysenbergh B, Nisolle M, Squifflet JL, Tebache L, Wyns C, Meuleman C, Tomassetti C. Conservative endometrioma surgery: The combined technique versus CO2-laser vaporization only (BLAST: Belgium LAser STudy): Clinical protocol for a multicenter randomized controlled trial. PLoS One. 2025 Mar 6;20(3):e0315709. doi: 10.1371/journal.pone.0315709. eCollection 2025.
Other Identifiers
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S62899
Identifier Type: -
Identifier Source: org_study_id