Gut Microbiome Studies in Patients With POEMS Syndrome and Other Plasma Cell Disorders
NCT ID: NCT06252948
Last Updated: 2025-09-22
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
240 participants
OBSERVATIONAL
2021-12-29
2028-12-29
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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MULTIPLE MYELOMA at diagnosis GROUP
Multiple myeloma (before starting chemotherapy, radiation or stem cell transplant
Non-interventional study (observational)
Participants undergo stool sample collection, complete surveys, and have their medical record reviewed on study.
Amyloid at diagnosis GROUP
AL amyloidosis (before starting chemotherapy or stem cell transplant)
Non-interventional study (observational)
Participants undergo stool sample collection, complete surveys, and have their medical record reviewed on study.
Poems at diagnosis GROUP
POEMS at diagnosis (before starting chemotherapy, radiation, or stem cell transplant
Non-interventional study (observational)
Participants undergo stool sample collection, complete surveys, and have their medical record reviewed on study.
Poems in Remission GROUP
POEMS in remission (no chemotherapy, radiation, or stem cell transplant for 2 years
Non-interventional study (observational)
Participants undergo stool sample collection, complete surveys, and have their medical record reviewed on study.
MGUS GROUP
MGUS -not treated newly diagnosed
Non-interventional study (observational)
Participants undergo stool sample collection, complete surveys, and have their medical record reviewed on study.
Health controls in same household GROUP
household member to be a healthy control (no chemotherapy or gastrointestinal illness to participate)
Non-interventional study (observational)
Participants undergo stool sample collection, complete surveys, and have their medical record reviewed on study.
Interventions
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Non-interventional study (observational)
Participants undergo stool sample collection, complete surveys, and have their medical record reviewed on study.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Pregnancy
* Substance abuse
* Antibiotics use or gastrointestinal endoscopy in the 3 months prior to the study participation
* Chronic gastrointestinal disorder
* Gastrointestinal surgeries in the past 2 years
* Chemotherapy (including anti-plasma cell treatment and steroids) or radiation treatment for cancer within the last 2 years or active cancer (other than plasma cell disorder)
18 Years
ALL
Yes
Sponsors
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Mayo Clinic
OTHER
Responsible Party
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Principal Investigators
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Angela Dispenzieri, M.D.
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic in Rochester
Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, United States
Countries
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Central Contacts
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Facility Contacts
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Related Links
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Mayo Clinic Clinical Trials
Other Identifiers
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NCI-2022-10547
Identifier Type: REGISTRY
Identifier Source: secondary_id
20-013316
Identifier Type: -
Identifier Source: org_study_id
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