Comparative Study of Metformin Versus Doxycycline in Moderate to Severe Adult Acne Vulgaris Patients.

NCT ID: NCT06252194

Last Updated: 2024-02-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

PHASE2

Total Enrollment

120 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-03-05

Study Completion Date

2024-03-31

Brief Summary

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The goal of this clinical trial is to compare the effect of doxycycline and metformin in treatment of acne vulgaris patients. The main question is aimed to answer is whether metformin is more effective than doxycycline in treatment of acne vulgaris patient or not.

Patients will be asked to take doxycycline along with tropical treatment in one group and metformin along with tropical treatment in another group.

Researcher will compare the clinical improvement in two groups.

Detailed Description

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Conditions

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Acne Vulgaris

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Group A

Metformin 500 mg twice daily along with topical retinoids for 12 weeks

Group Type EXPERIMENTAL

Metformin and doxycycline

Intervention Type DRUG

Metformin 500 mg tablet twice daily

Group B

Doxycycline 100 mg twice daily along with topical retinoids for 12 weeks

Group Type ACTIVE_COMPARATOR

Metformin and doxycycline

Intervention Type DRUG

Metformin 500 mg tablet twice daily

Interventions

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Metformin and doxycycline

Metformin 500 mg tablet twice daily

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

Newly diagnosed moderate and severe AV patients diagnosed by a dermatologist

\-

Exclusion Criteria

* Patients receiving topical retinoids within last two months
* Pregnancy and lactation
* History of corticosteroids intake
* Suffering from malignancy or any cosmetic induced acne
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

OTHER

Sponsor Role lead

Responsible Party

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Dr. Muhammad Marnush

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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BSMMU

Dhaka, , Bangladesh

Site Status RECRUITING

Countries

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Bangladesh

Central Contacts

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Muhammad Marnush, MBBS

Role: CONTACT

88001714558447

Facility Contacts

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registrar

Role: primary

Other Identifiers

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BSMMU/2022/11379

Identifier Type: -

Identifier Source: org_study_id

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