Pyroptosis and Ferroptosis in the Pathophysiology of Lymphedema

NCT ID: NCT06237907

Last Updated: 2024-02-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-09-20

Study Completion Date

2026-01-12

Brief Summary

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The project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.

Detailed Description

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This project aims to investigate the expression of cell death through apoptosis and iron-dependent cell death in the subcutaneous adipose tissue of patients with lymphedema. The study also seeks to explore the roles of these processes among lymphatic endothelial cells, adipocytes, and macrophages, and their association with lymphedema, thus gaining insights into the pathophysiological mechanisms of lymphedema. Furthermore, the project aims to compare the differences in the expression of cell death through apoptosis and iron-dependent cell death after the reduction of edema symptoms following lymphedema surgery in patients.

Conditions

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Lymphedema

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients underwent surgery

Patients underwent lymphedema surgery

Intervention Type OTHER

Patients who have developed lymphedema and undergone lymphedema surgery.

Patients underwent surgery without LVA

Intervention Type OTHER

For patients who have not experienced lymphedema but require surgery due to other disease such as cancer, trauma, chronic wounds, skin defects, etc.

Interventions

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Patients underwent lymphedema surgery

Patients who have developed lymphedema and undergone lymphedema surgery.

Intervention Type OTHER

Patients underwent surgery without LVA

For patients who have not experienced lymphedema but require surgery due to other disease such as cancer, trauma, chronic wounds, skin defects, etc.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Control Group: Patients who have not experienced lymphedema but require surgery due to other diseases such as cancer, trauma, chronic wounds, skin defects, etc.
* Experimental Group: Patients who have lymphedema and undergone lymphedema surgery.

Exclusion Criteria

* 1\. Individuals with venous thrombosis, chronic heart failure, and renal failure.
* 2\. Vulnerable populations, individuals with limited mobility, pregnant women, and minors.
* 3\. Those expected to be unable to attend follow-up visits or complete the study smoothly.
* 4\. Participants who express doubts about the trial and cannot provide satisfactory answers.
Minimum Eligible Age

20 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chang Gung Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Ching-Hua Hsieh, PhD

Role: CONTACT

+886-7-7317123 ext. 2947

Facility Contacts

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Hsiao-Yun Hsieh, MSc

Role: primary

+886-7-7317123 ext. 2947

Other Identifiers

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202201327B0

Identifier Type: -

Identifier Source: org_study_id

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