Muscle Fatigability and Trip-specific Fall Risk in Adults With Knee Osteoarthritis
NCT ID: NCT06229691
Last Updated: 2025-09-30
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
24 participants
INTERVENTIONAL
2024-05-14
2025-08-27
Brief Summary
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* Does fatigue increase the risk of tripping while walking? and
* Does fatigue increase the risk of falling in response to a trip while walking? Participants will
* Complete questionnaires
* Wear a device that measures physical activity for 5-7 days
* Complete a 30 minute walk on a treadmill
* Complete the following before and after the treadmill walk:
* Computer test to measure mental fatigue
* Maximal strength testing
* Balance test
Researchers will compare adults with and without knee osteoarthritis to see if fall risk in adults with knee osteoarthritis is affected more by walking activity compared to adults without knee osteoarthritis.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
BASIC_SCIENCE
NONE
Study Groups
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Healthy
30 minute treadmill walk
Participants will walk on a treadmill at their preferred speed for 30 minutes. One minute "challenge" periods will occur at minutes 7, 17, and 27, when the treadmill speed will increase by 50%. This walk will induce a magnitude of muscle fatigue corresponding to an individual participant's fatigability.
Knee osteoarthritis
30 minute treadmill walk
Participants will walk on a treadmill at their preferred speed for 30 minutes. One minute "challenge" periods will occur at minutes 7, 17, and 27, when the treadmill speed will increase by 50%. This walk will induce a magnitude of muscle fatigue corresponding to an individual participant's fatigability.
Interventions
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30 minute treadmill walk
Participants will walk on a treadmill at their preferred speed for 30 minutes. One minute "challenge" periods will occur at minutes 7, 17, and 27, when the treadmill speed will increase by 50%. This walk will induce a magnitude of muscle fatigue corresponding to an individual participant's fatigability.
Eligibility Criteria
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Inclusion Criteria
* presence of occasional to frequent knee pain
* knee pain that is primarily in the medial knee joint compartment
* minimal morning joint stiffness
For all participants:
* able to walk continuously for 30 minutes without an assistive device
Exclusion Criteria
* history of joint replacement
* lower-extremity joint injections within 3 months
* history of stroke or other neurological condition
* cardiovascular or pulmonary conditions that limit daily activity or that preclude participation in exercise
* history of major lower extremity or back injury or pain (except for knee osteoarthritis)
* history of lower extremity amputation
* use an orthotic or prosthetic to walk
* use of beta blockers or other medications that affect fatigue
* use of medications that affect balance
* diabetic neuropathy
* acute illness or the presence of lesions on the torso or lower extremities
* BMI greater than 35
* body weight over 265 lbs
55 Years
70 Years
ALL
Yes
Sponsors
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National Institute of General Medical Sciences (NIGMS)
NIH
University of Delaware
OTHER
Responsible Party
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Locations
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University of Delaware
Newark, Delaware, United States
Countries
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Other Identifiers
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1924071
Identifier Type: -
Identifier Source: org_study_id
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