Association Between Handgrip Strength and Small Airway Disease in Patients with Stable Chronic Obstructive Pulmonary Disease

NCT ID: NCT06223139

Last Updated: 2025-01-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

64 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-03-01

Study Completion Date

2024-05-31

Brief Summary

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The goal of this observational study is to investigate the correlation between handgrip strength and small airway disease among patients with chronic obstructive pulmonary disease (COPD). The main question it aims to answer is:

• Is handgrip strength correlated with small airway disease in COPD patients? Participants will perform handgrip strength test and impulse oscillometry (IOS).

Detailed Description

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This is a cross-sectional study in COPD patients. COPD patients aged 40 years or older were included. Handgrip strength test and impulse oscillometry will be tested in each patient. Handgrip strength will be measured using a hand dynamometer. Small airway disease will be assessed using IOS.

Conditions

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COPD

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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COPD

COPD patients aged 40 years or older with a post-bronchodilator ratio of forced expiratory volume in one second (FEV1) to forced vital capacity (FVC) \<0.7.

Handgrip strength

Intervention Type DIAGNOSTIC_TEST

Handgrip strength will be measured by 3 efforts.

Interventions

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Handgrip strength

Handgrip strength will be measured by 3 efforts.

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* COPD patients aged 40 years or older
* Confirmed diagnosis by spirometry (post-bronchodilator FEV1/FVC \<0.7)
* Smoking history 10 pack-years or more

Exclusion Criteria

* COPD exacerbation within 3 months
* Inability to perform handgrip strength test or impulse oscillometry
Minimum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Thammasat University

OTHER

Sponsor Role lead

Responsible Party

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Narongkorn Saiphoklang, MD

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Narongkorn Saiphoklang, MD

Role: PRINCIPAL_INVESTIGATOR

Thammasat University Faculty of Medicine

Locations

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Thammasat University Faculty of Medicine

Pathum Thani, Changwat Pathum Thani, Thailand

Site Status

Countries

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Thailand

References

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Keawon T, Saiphoklang N. Association between handgrip strength and small airway disease in patients with stable chronic obstructive pulmonary disease. Ther Adv Respir Dis. 2024 Jan-Dec;18:17534666241281675. doi: 10.1177/17534666241281675.

Reference Type DERIVED
PMID: 39367749 (View on PubMed)

Other Identifiers

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MTU-EC-IM-0-215/65

Identifier Type: -

Identifier Source: org_study_id

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