Radiomics Analysis Based on MRI to Detect Brucella Spondylitis

NCT ID: NCT06220500

Last Updated: 2024-01-24

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-01-01
• Study Completion Date: 2024-12-31

Brief Summary

Brucella spondylitis, an infectious spinal disease caused by the invasion of Brucella bacteria into the body. Its diagnosis relies mainly on laboratory and imaging tests. Due to the limited diagnostic ability of X-ray and CT for Brucella spondylitis, MRI has become the main diagnostic tool. In recent years, functional magnetic resonance technology has demonstrated great advantages in the diagnosis and therapeutic evaluation of brucellosis spondylitis, which can provide pathophysiologic information about the disease and is also a noninvasive and noninvasive diagnostic tool with a broader application prospect. Radiomics, an emerging approach, has also shown better diagnostic efficacy for this disease.

Detailed Description

The investigators will incorporate 100 confirmed cases of Brucella spondylitis (BS) patients diagnosed at Affiliated Hospital of Inner Mongolia Medical University. The patients receive routine scan with a Siemens Skyra 3.0T MRI scanner and the investigators collect clinical data and blood test results from the patients.The investigators segment the affected vertebral bodies by ITK-SNAP software on STIR images to create three-dimensional regions of interest. Then use Onekey software to extract radiomics features from the affected vertebral bodies. Employed t-tests and Lasso regression to select radiomics features. Then separately use radiomics features and combining it with clinical information to build random vector machine(SVM) and random forest(RF) models . All the models are constructed in the training set and their performance are evaluated on the validation set.

Conditions

Brucella Spondylitis

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

1. Outpatients/Inpatients

2. Age 18-70 years

3. Meet diagnostic criteria for brucellosis

4. Meet symptoms of brucellosis spondylitis

5. Voluntarily sign an informed consent form

6. Can cooperate with MRI examination

Exclusion Criteria

1. Patients with serious diseases of other systems

2. History of malignant tumors of the vertebral body

3. History of tuberculosis

4. Contraindications to magnetic resonance imaging

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

The Affiliated Hospital of Inner Mongolia Medical University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Peng fei Qiao, MD

Role: STUDY_DIRECTOR

The Affiliated Hospital of Inner Mongolia Medical University

Locations

Affiliated Hospital of Inner Mongolia Medical University

Hohhot, Inner Mongolia, China

Site Status: RECRUITING

Countries

China

Central Contacts

Peng fei Qiao, MD

Role: CONTACT

24853170@qq.com

15904718239

Facility Contacts

Peng fei Qiao

Role: primary

24853170@qq.com

15904718239

Other Identifiers

AHInnerMongolia-BS

Identifier Type: -

Identifier Source: org_study_id