Clinical Study of PET/CT and Association With Metabolic Syndrome/Depressive Symptoms in Psoriasis

NCT ID: NCT01661127

Last Updated: 2014-11-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

10 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-06-30

Study Completion Date

2015-12-31

Brief Summary

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Psoriasis is associated with increases in markers of inflammation in the skin and blood and increasingly is thought to be a systemic inflammatory disease and risk factor for incident diabetes mellitus, myocardial infarction, stroke, and premature cardiovascular death. Furthermore, it is important for clinicians to be aware that psoriasis can have a substantial emotional impact on an individual, which is not necessarily related to the extent of skin disease.

FDG-PET/CT represents an innovative approach to studying systemic inflammation in a manner that is sensitive, quantifiable, and anatomically localizable. Also, recent study show that chronic disease such as end stage renal disease with depressive symptoms have decreased cerebral glucose metabolism in several brain areas in F-18-FDG PET/CT. So this protocol was designed to evaluate usefulness of PET/CT to detect systemic inflammation and abnormality of cerebral glucose metabolism and association with metabolic syndrome/major depressive symptoms in patients with psoriasis.

Detailed Description

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10 Patients with psoriasis

1. Evaluate PASI score
2. Evaluate comorbidity with metabolic syndrome

* Body mass index(BMI)
* Checking blood pressure
* Checking blood sugar
* Smoking and drinking history
* Checking blood cholesterol level
* Risk factors of cardiovascular disease
3. PET/CT for measuring the extent and site of psoriasis with inflammation

Conditions

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Psoriasis Metabolic Syndrome Depression

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Histological diagnosis of plaque type psoriasis
* at least 18 years old

Exclusion Criteria

* those who cannot understand questionnaire
* those who take antidepressant
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pusan National University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Byung-Soo Kim, Ph D.

Role: STUDY_CHAIR

Pusan National University Hospital

Locations

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Department of dermatology, Pusan National University Hospital

Busan, Busan, South Korea

Site Status RECRUITING

Countries

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South Korea

Central Contacts

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Byung-Soo Kim, Ph D.

Role: CONTACT

82-51-240-7338

Facility Contacts

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Byung-Soo Kim, Ph D.

Role: primary

82-51-240-7338

Other Identifiers

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PNUHDM-psoriasis

Identifier Type: -

Identifier Source: org_study_id

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