Redirecting Immune, Lipid and Metabolic Drivers of Early Cardiovascular Disease: The RESET Cohort Study

NCT ID: NCT06211868

Last Updated: 2024-10-15

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

3000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2024-03-01

Study Completion Date

2030-09-01

Brief Summary

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Project RESET is a Singapore National Medical Research Council Large Collaborative Grant funded program that brings together a nationwide community of cardiovascular, metabolic, and digital health researchers, as well as clinicians across primary and tertiary care to study the immune, lipid and metabolic drivers of early cardiovascular disease. RESET incorporates a nested randomised controlled trials (RCT) to test the use of a combined digital wearable and AI-human symbiotic lifestyle intervention to halt or reverse the progression of early disease.

Detailed Description

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Conditions

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Cardiovascular Diseases Metabolic Syndrome Non-Alcoholic Fatty Liver Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Observational cohort

No interventions assigned to this group

Randomised cohort

Digital wearable and AI-human symbiotic lifestyle intervention

Intervention Type BEHAVIORAL

Digital wearable and AI-human symbiotic lifestyle intervention

Interventions

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Digital wearable and AI-human symbiotic lifestyle intervention

Digital wearable and AI-human symbiotic lifestyle intervention

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* 40-70 years old
* ASCVD (atherosclerotic cardiovascular disease) score of 5% and higher

Exclusion Criteria

* Previous major cardiovascular disease (myocardial infarction, heart failure, ischemic stroke)
* Limited life expectancy
* Other ongoing unstable medical conditions
* Pregnant women
Minimum Eligible Age

40 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National University of Singapore

OTHER

Sponsor Role collaborator

National University Hospital, Singapore

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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NUS

Singapore, , Singapore

Site Status RECRUITING

Countries

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Singapore

Central Contacts

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Hayang Yang, PhD

Role: CONTACT

+6582810448

Facility Contacts

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Hayang Yang, PhD

Role: primary

Other Identifiers

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RESET

Identifier Type: -

Identifier Source: org_study_id

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