Prehabilitative Exercise Prior to Immobilization

NCT ID: NCT06205784

Last Updated: 2025-09-19

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 64 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2024-01-06
• Study Completion Date: 2025-06-01

Brief Summary

This is a 10-week human study involving 24 younger (20-35 y) and 24 older (65-85 y) healthy individuals. All participants will undergo unilateral immobilization of a knee for 7-10 days, followed by 4 weeks of heavy resistance exercise training (HReT). Half of the participants (12 younger and 12 older) will also undergo 4 weeks HReT prior to the immobilization. Prehabilitative exercise may confer protective effects on subsequent immobilization, and the various underlying mechanisms involved

Conditions

Sarcopenia; Skeletal Muscle Atrophy; Disuse Atrophy

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: SINGLE

Study Groups

Prehab

Group Type: EXPERIMENTAL

Prehabilitative exercise

Intervention Type: OTHER

3-4 weeks of heavy resistance exercise

NoTrain

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Prehabilitative exercise

3-4 weeks of heavy resistance exercise

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Age: Between 20-35 years old or between 65-85 years old.
• BMI: Between 18.5 and 35 kg/m2.
• Healthy and well, with normal dietary habits (not vegan).

Exclusion Criteria

• More than one muscle biopsy previously taken from both vastus lateralis muscles.
• Smoking.
• Pregnancy.
• Past or present substance or alcohol abuse.
• Medical/surgical conditions that are assessed to affect protein synthesis or the participant's involvement in the trial.
• Knee pain that could affect the completion of the training intervention.
• High intake of supplements that increase the risk of bleeding during muscle biopsy (such as fish oil and ginger).
• Participation in regular strength training within the past year.
• Regular participation in structured sports.
• Current use of blood-thinning medication.
• Previous participation in trials involving oral intake of heavy water.
• Metal in the body preventing MRI scanning.
• For the older group, not having gone through menopause, and for the younger group, not having a regular menstrual cycle.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 85 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Bispebjerg Hospital

OTHER

Sponsor Role: lead

Responsible Party

Casper Soendenbroe

Postdoc

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Institute of Sports Medicine Copenhagen

Copenhagen, Capital Region, Denmark

Countries

Denmark

Other Identifiers

BBH164

Identifier Type: -

Identifier Source: org_study_id