İmportance of Scattered White Spots Detected in the Duodenum and Their Relationship wıth Zonulin
NCT ID: NCT06200129
Last Updated: 2024-01-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
93 participants
INTERVENTIONAL
2023-09-01
2023-12-01
Brief Summary
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Detailed Description
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Patients included 63 individuals with identified SWS during EGD and 30 patients with a normal appearance of the duodenal mucosa were selected as the control group. SWS lesions were categorized into two groups, grade 1 and grade 2, based on the degree of density and endoscopic appearance. Biopsies were taken from the duodenum, antrum, and corpus. It was examined for IL, CND, giardiasis, and villous atrophy. Venous blood samples were collected from all patients for serum zonulin levels.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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sws grade 1
The group that defined as scattered white spots on the normal duodenal mucosa that could not be wiped away by washing, appearing as white spots
sws grade 1
Blood for zonulin level was drawn from the group of patients with typical white lesions in the duodenum, called grade 1.
sws grade 2
The group that defined as a diffuse or patchy white appearance on villi that could not be wiped away by washing on the mucosa.
sws grade 2
Blood for zonulin level was drawn from the group of patients with typical white lesions in the duodenum, called grade 2
control
The group with a normal appearance of the duodenal mucosa, where scattered white spots were not detected.
control
Group of patients without scattered white lesions in the dueodenum on endoscopy.
Interventions
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sws grade 1
Blood for zonulin level was drawn from the group of patients with typical white lesions in the duodenum, called grade 1.
sws grade 2
Blood for zonulin level was drawn from the group of patients with typical white lesions in the duodenum, called grade 2
control
Group of patients without scattered white lesions in the dueodenum on endoscopy.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* acute kidney failure
* chronic kidney failure
* type-1 diabetes
* inflammatory bowel disease
* duodenal ulcer,
* duodenal tumor
* autoimmune diseases
18 Years
80 Years
ALL
Yes
Sponsors
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Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
OTHER
Responsible Party
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Semih Sezer
clinic physician
Principal Investigators
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semih sezer
Role: PRINCIPAL_INVESTIGATOR
clinic physician
Locations
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Dr. Abdurrahman Yurtaslan Oncology Training and Research Hospital
Ankara, , Turkey (Türkiye)
Countries
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References
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Tas A, Koklu S, Beyazit Y, Akbal E, Kocak E, Celik H, Biyikoglu I. The endoscopic course of scattered white spots in the descending duodenum: a prospective study. Gastroenterol Hepatol. 2012 Feb;35(2):57-64. doi: 10.1016/j.gastrohep.2011.11.010. Epub 2012 Jan 20.
Fasano A, Shea-Donohue T. Mechanisms of disease: the role of intestinal barrier function in the pathogenesis of gastrointestinal autoimmune diseases. Nat Clin Pract Gastroenterol Hepatol. 2005 Sep;2(9):416-22. doi: 10.1038/ncpgasthep0259.
Biyikoglu I, Babali A, Cakal B, Koklu S, Filik L, Astarci MH, Ustun H, Ustundag Y, Akbal E. Do scattered white spots in the duodenum mark a specific gastrointestinal pathology? J Dig Dis. 2009 Nov;10(4):300-4. doi: 10.1111/j.1751-2980.2009.00399.x.
Other Identifiers
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zonulinsws
Identifier Type: -
Identifier Source: org_study_id
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