Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
590 participants
OBSERVATIONAL
2022-03-31
2026-10-31
Brief Summary
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Detailed Description
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Despite recent genetic progress AID pathophysiology is only partly understood, especially in the case of unclassified AID.
Mast cells (MC) are innate immune cells associated with a spectrum of disease between systemic mastocytosis and mast cell activation syndrome (MCAS). In MCAS, patients have various symptoms including abdominal pain, bloating, pruritus, flush, anxiety, fatigue, among which some are similar to those seen in patients with AID. The implication of MC has been shown in cryopyrin associated periodic syndrome (CAPS).
Our hypothesis is that MC could be involved in AID pathophysiology,
In order to test this hypothesis, we plan to study :
* clinical MC activation symptoms via a standardized clinical score
* biological MC mediators : by measuring total serum tryptase and histamine in total blood, plasma and urine
* MC infiltration on gastro-intestinal (GI) tract and cutaneous biopsies We will compare clinical MC activation score in AID patients to patients with mastocytosis, with other inflammatory diseases, and with healthy controls.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients with AID
No interventions assigned to this group
Control patients with mastocytosis
No interventions assigned to this group
Control patients with normal digestive biopsy
No interventions assigned to this group
Control patients with renal biopsy
No interventions assigned to this group
Control patients with inflammatory disease
No interventions assigned to this group
Healthy control from healthcare workers
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Healthy adult controls, age- and sex-matched with MAI patients, and controls with mastocytosis, an immuno-inflammatory disease.
* Subject affiliated to or entitled to a social security scheme
* Collection of the patient's or healthy control's non-opposition
Exclusion Criteria
* Subjects who do not speak French
* Subject deprived of liberty or under legal protection.
18 Years
ALL
No
Sponsors
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Institut Imagine
UNKNOWN
Assistance Publique - Hôpitaux de Paris
OTHER
Responsible Party
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Principal Investigators
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Sophie GEORGIN-LAVIALLE, PU-PH
Role: PRINCIPAL_INVESTIGATOR
Assistance Publique - Hôpitaux de Paris
Locations
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Service de Médecine Interne
Paris, , France
Countries
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Central Contacts
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Other Identifiers
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APHP210126
Identifier Type: -
Identifier Source: org_study_id
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