ICU Combined Assessment of Cardio-Respiratory Exercise

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-12-15

Study Completion Date

2028-07-31

Brief Summary

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This study aims to investigate how sepsis and critical illness can impair the cardiovascular system and microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle weakness/dysfunction or ICU-Acquired Weakness (ICU-AW) and exercise limitations.

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Detailed Description

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This longitudinal study will assess cardiovascular fitness and microvascular function through two (2) follow-ups after ICU discharge: at (i) 6 months, and (ii) 12 months. The goal is to understand how microvascular dysfunction contributes to ICU-AW and long-term exercise limitation in ICU survivors.

Specific goals are:

1. Evaluate peak oxygen uptake and oxygen on/off kinetics in ICU survivors using a standardized cardiopulmonary exercise test (CPET) protocol.
2. Characterize skeletal muscle microvascular function in ICU survivors using high-resolution NIRS during CPET protocol.
3. Determine the association between impairments in skeletal muscle microvascular oxygen delivery and cardiovascular blood flow regulation in ICU survivors.

Conditions

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ICU Acquired Weakness Sepsis Shock Critical Illness Microcirculation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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ICU survivors

Patients who have received prolonged mechanical ventilation (7 days or more) in the intensive care unit (ICU), and have been discharged from hospital.

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients who have received mechanical ventilation for at least 7 days in the intensive care unit (ICU) and have subsequently been discharged from hospital.

Exclusion Criteria

* Unable to provide consent
* Trajectory of health expected to be significantly limited in the upcoming 12 months
* those who self-report that they cannot climb at least one flight of stairs due to limited exercise capacity
* have significant orthopedic or musculoskeletal impairment affecting mobility
* have a medical history of neuromuscular disease
* ongoing respiratory limitations (i.e., supplemental oxygen)
* significant heart disease (i.e. ejection fraction less than 30%, unstable ischemic heart disease, severe valvular heart disease)
* a body mass index (BMI) of ≥ 40 kg/m2 (impacting NIRS signal due to adipose tissue thickness)
* if participant's primary residence is a significant distance from Winnipeg

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No