Machine Learning Predicts Survival and Mutations in Ovarian Metastases of Colorectal Cancer

NCT ID: NCT06192030

Last Updated: 2024-01-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-08-27

Study Completion Date

2025-08-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The study aimed to develop and validate models to predict survival outcome and key mutations in patients with ovarian metastases of colorectal cancer, as well as to compare the differential gene expression between long-survival group and short-survival group.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The investigator performed a retrospective-prospective cohort study with the aim of developing and validating comprehensive models to predict survival outcome and key mutations from multimodality data in patients with ovarian metastases of colorectal cancer. Secondly, the investigator aimed to compare the differential gene expression between long-survival group and short-survival group.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Ovarian Metastases of Colorectal Cancer

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Retrospective cohort

The cohort was retrospectively enrolled in The Sixth Affiliated Hospital, Sun Yat-sen University from August 2010 to August 2022. It is a training cohort.

Prediction model

Intervention Type OTHER

We develop and validate clinical models to predict patient survival and gene signatures in ovarian metastases of colorectal cancer.

Prospective cohort

The same inclusion/exclusion criteria were applied for the same center prospectively. It is a validation cohort.

Prediction model

Intervention Type OTHER

We develop and validate clinical models to predict patient survival and gene signatures in ovarian metastases of colorectal cancer.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Prediction model

We develop and validate clinical models to predict patient survival and gene signatures in ovarian metastases of colorectal cancer.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Histologically confirmed colorectal cancer
* Unilateral or bilateral ovarian masses confirmed by peroperative imaging examination
* Patient requiring resection of their ovarian and/or peritoneal carcinomatosis
* 18 ≤ Age ≤ 85
* World Health Organization performance status ≤ 1
* Life expectancy \> 12 weeks
* Adequate haematological, liver and renal function
* Patient information and signature of the informed consent form before the start of any treatment procedures

Exclusion Criteria

* Ovarian metastases of origin other than colorectal
* Primary ovarian tumor
* Clinical data missing
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Sixth Affiliated Hospital, Sun Yat-sen University

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Sixth Affiliated Hospital, Sun Yat-sen University

Guangzhou, Guangdong, China

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

China

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Yuanxin Zhang, MD

Role: CONTACT

8617372001179

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Huaiming Wang, MD

Role: primary

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

wanghm7

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Prognostic Biomarker for CRC
NCT03928652 UNKNOWN