Comparison of Expandable and Fixed Size Cryoballoon for the Treatment of Paroxysmal Atrial Fibrillation

NCT ID: NCT06183879

Last Updated: 2024-05-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-01-01

Study Completion Date

2026-01-01

Brief Summary

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The goal of this clinical trial is to compare two different, market approved, cryoballoon devices for the treatment of paroxysmal atrial fibrillation (AF).

The main aims of the study are:

* to compare the efficacy of two ablation devices (acute and 1 year success rates)
* to compare the procedural characteristics (procedure duration, fluoroscopy duration, ablation time
* to compare the complication rates

Participants who have indication for cryoballoon ablation of AF will be randomized in 1:1 fashion to older fixed size cryoballoon and newer expandable cryoballoon. Standard of care cryoballoon procedure will be performed alongside with standard postprocedural follow-up.

• to compare the complication rates

Participants who have indication for cryoballoon ablation of AF will be randomized in 1:1 fashion to older fixed size cryoballoon and newer expandable cryoballoon.

Detailed Description

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Patients suffering from paroxysmal atrial fibrillation who are scheduled (independently of this study) for cryoballoon pulmonary vein isolation will be informed about the study and potential risks. All patients who give written informed consent will be randomized to 4th generation Artic Front Advance Pro device (fixed size balloon of 28 mm) and Polar X Fit device (28-31 mm expandable balloon). The ablation procedure will be performed in standard of care fashion. Also, standard postprocedural follow up of the patients will be scheduled with outpatient clinic visits and 24-hour Holters and 3, 6 and 12 months, and yearly thereafter. Extra visits will be scheduled in the case of symptoms/palpitations.

Standard patient and procedural data will be collected alongside with the information obtained in the follow up.

Conditions

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Atrial Fibrillation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

1:1 randomization to two different cryoballoon devices
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Medtronic 4th gen balloon

Cryoballoon pulmonary vein isolation with Medtronic Artic Front Advance Pro 28 mm fixed size cryoballoon

Group Type ACTIVE_COMPARATOR

cryoballoon pulmonary vein isolation (Medtronic 4th gen balloon)

Intervention Type DEVICE

Standard of care cryoballoon pulmonary vein isolation with Medtronic 4th gen balloon

Boston 2nd gen balloon

Cryoballoon pulmonary vein isolation with Polar X Fit, 28 to 31 mm expandable cryoballoon

Group Type ACTIVE_COMPARATOR

cryoballoon pulmonary vein isolation (Boston 2nd gen balloon)

Intervention Type DEVICE

Standard of care cryoballoon pulmonary vein isolation with Boston 2nd gen balloon

Interventions

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cryoballoon pulmonary vein isolation (Medtronic 4th gen balloon)

Standard of care cryoballoon pulmonary vein isolation with Medtronic 4th gen balloon

Intervention Type DEVICE

cryoballoon pulmonary vein isolation (Boston 2nd gen balloon)

Standard of care cryoballoon pulmonary vein isolation with Boston 2nd gen balloon

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* paroxysmal atrial fibrillation
* patient scheduled for cryoballoon pulmonary vein isolation regardless of this study

Exclusion Criteria

* unwilling to sing the informed consent Left atrium size \> 55 mm Uncontrolled heart failure (NYHA III-IV) Intracardiac thrombi
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Zagreb

OTHER

Sponsor Role lead

Responsible Party

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Vedran Velagic

MD, PhD, Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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KB Dubrava

Zagreb, Please Select, Croatia

Site Status RECRUITING

KBC Zagreb

Zagreb, , Croatia

Site Status RECRUITING

Countries

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Croatia

Central Contacts

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Vedran Velagic, MD, PhD

Role: CONTACT

+385917929284

Facility Contacts

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Ante Lisicic, MD

Role: primary

+385915710116

Vedran Velagić, MD, PhD

Role: primary

0917929284

Other Identifiers

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PolarvsAFA

Identifier Type: -

Identifier Source: org_study_id

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