Regional Distribution of Ventilation at Different Respiratory Rates
NCT ID: NCT06171477
Last Updated: 2024-05-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
15 participants
INTERVENTIONAL
2024-05-02
2024-12-31
Brief Summary
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Detailed Description
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A less harmful mode of ventilation could possible lead to a more optimal ventilation with avoidance of ventilator induced lung injuries. The project will investigate if volume controlled ventilation with a higher respiratory frequency can be used in this purpose.
The researchers intend to investigate patients, without previously known lung disease, undergoing robot-assisted laparoscopic prostatectomy. After the patients have given informed consent, they will be included in the project. The distribution of ventilation will be monitored with electric impedance tomography (EIT). Once the patients have been anaesthetized, positioned with the head down and the surgical procedure have been started with insufflation of carbon dioxide we will start our test.
The investigators will perform three episodes of standardized ventilation with the respiratory rate (RR) of 20, 40 and 60. With a higher RR the tidal volume will be reduced tom maintain a constant inhaled minute volume. Data will be collected from the EIT-equipment, the anaesthesia machine and the monitoring system.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
SINGLE
Study Groups
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20-40-60
Ventilation 20-40-60
The respiratory rate during mechanical ventilation will be altered from 20 to 40 and finally to 60 breaths per minute.
60-40-20
Ventilation 60-40-20
The respiratory rate during mechanical ventilation will be altered from 60 to 40 and finally to 20 breaths per minute.
40-60-20
Ventilation 40-60-20
The respiratory rate during mechanical ventilation will be altered from 40 to 60 and finally to 20 breaths per minute.
Interventions
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Ventilation 20-40-60
The respiratory rate during mechanical ventilation will be altered from 20 to 40 and finally to 60 breaths per minute.
Ventilation 60-40-20
The respiratory rate during mechanical ventilation will be altered from 60 to 40 and finally to 20 breaths per minute.
Ventilation 40-60-20
The respiratory rate during mechanical ventilation will be altered from 40 to 60 and finally to 20 breaths per minute.
Eligibility Criteria
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Inclusion Criteria
* \> 18 years
* Consent to take part in the study
Exclusion Criteria
* Previously known lung disease
* Insufficient skills in Swedish language to understand information about the study
18 Years
MALE
No
Sponsors
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Region Örebro County
OTHER
Responsible Party
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Principal Investigators
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Pether Jildenstål, PhD
Role: STUDY_DIRECTOR
Örebro University, Sweden
Locations
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Region Örebro län
Örebro, , Sweden
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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281122
Identifier Type: -
Identifier Source: org_study_id
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