Number of Previous Cesarean Sections on the Results of Angiogenic Factors.

NCT ID: NCT06166303

Last Updated: 2025-08-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

NOT_YET_RECRUITING

Total Enrollment

540 participants

Study Classification

OBSERVATIONAL

Study Start Date

2025-10-01

Study Completion Date

2026-03-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Hypertensive disorders of pregnancy (HPT) are an important cause of maternal-feto-neonatal morbidity and mortality, being one of the three leading causes of maternal death in our country and in developing countries. The only cure for THE is termination of pregnancy, which ends up being a decision in which gestational age and maternal risks must be balanced. Angiogenic factors have come to occupy an indispensable place in the arsenal of tools that can be used to separate the patient with a high likelihood of complications from those in whom prolongation of pregnancy could represent an important neonatal benefit.

Although the usefulness of angiogenic factors in these scenarios is known, little is known about the effects that other conditions might have on their serum levels, mainly those that have an effect on trophoblastic invasion, the process that initiates implantation of the pregnancy in the endometrium. The purpose of the present study is to assess the effect that a history of uterine surgery, such as caesarean section, might have on angiogenic factor scores in subjects with no history of a hypertensive disorder of pregnancy.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cesarean Section

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Previous Cesarean Section

Subjects with one or more previous cesarean sections

sFlt-1/PGIF

Intervention Type DIAGNOSTIC_TEST

Index of sFlt-1/PGIF

No Cesarean

Subjects scheduled for an elective or urgent cesarean, but no history of previous cesarean section

sFlt-1/PGIF

Intervention Type DIAGNOSTIC_TEST

Index of sFlt-1/PGIF

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

sFlt-1/PGIF

Index of sFlt-1/PGIF

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* 36 weeks of gestation or more
* Singleton pregnancy
* Previous cesarean section (case)

Exclusion Criteria

* Vasculitis
* Twin pregnancy
* Chronic endometritis
* Smoking
* Lupus
* Renal failure
* Liver disease
* Thrombocytopenia
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Saint Thomas Hospital, Panama

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Osvaldo A. Reyes T.

Head of the research deparment

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Osvaldo Reyes

Role: PRINCIPAL_INVESTIGATOR

Hospital Santo Tomás

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Saint Thomas H

Panama City, Provincia de Panamá, Panama

Site Status

Countries

Review the countries where the study has at least one active or historical site.

Panama

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Osvaldo Reyes, MD

Role: CONTACT

+507 65655041

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

U1111-1301-2580

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Mechanistic Underpinnings of Preeclampsia
NCT06567899 NOT_YET_RECRUITING