The Decline in Walking Performance in Adults With Cerebral Palsy

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-05-02

Study Completion Date

2024-07-10

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Due to an early brain injury occurring in antenatal or postnatal, cerebral palsy (CP) causes alteration in motor function with posture and gait disorders. It is commonly observed motor performance degradation during adulthood, and the underlying pathophysiology remains poorly known.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Activity and Participation in Ambulatory Cerebral Palsy

NCT01217242

Cerebral Palsy

COMPLETED

Quantifying Energetic Demands of Walking for People With Cerebral Palsy

NCT04303078

Cerebral Palsy

COMPLETED NA

Targeted Hip Strength Training in Children With Cerebral Palsy (CP)

NCT01633736

Cerebral Palsy

UNKNOWN PHASE3

Influence of Fatigue on the Walking Pattern in Cerebral Palsy Patients.

NCT04129749

Cerebral Palsy

WITHDRAWN

Static and Dynamic Postural Stability in Cerebral Palsy Children

NCT01799304

CP (Cerebral Palsy) Diplegia Hemiplegia +1 more

COMPLETED PHASE3

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

One of the hypotheses to explain the decline in walking capacities in adults with CP is their greater fatigability, that could be related to energy overconsumption (due to the specific biomechanical constraints of their walking pattern) and/or the occurrence of early sarcopenia affecting the compensatory muscle mechanisms commonly seen in children to compensate for architectural disorders and posture alterations. To optimize prevention and/or therapy in these patients, it is crucial to better understand the aetiology of fatigability and its role in the decline in walking performance.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Muscle Spasticity Paralysis; Cerebral

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Patients with cerebral palsy

A specially adapted recumbent cycle ergometer with the ability to quickly transform into an isometric dynamometer will be used to assess fatigability development during a task to failure. Throughout the task, which consists of blocks of 3 minutes, neuromuscular assessments will take place to determine the evolution of fatigability and its peripheral and central determinants.

Group Type EXPERIMENTAL

Fatigability assessment

Intervention Type OTHER

An isometric dynamometer will be used to assess fatigability development during a task to failure. Throughout the task, which consists of blocks of 3 minutes, neuromuscular assessments will take place to determine the evolution of fatigability and its peripheral and central determinants.

Healthy people

A specially adapted recumbent cycle ergometer with the ability to quickly transform into an isometric dynamometer will be used to assess fatigability development during a task to failure. Throughout the task, which consists of blocks of 3 minutes, neuromuscular assessments will take place to determine the evolution of fatigability and its peripheral and central determinants.

Group Type ACTIVE_COMPARATOR

Fatigability assessment

Intervention Type OTHER

An isometric dynamometer will be used to assess fatigability development during a task to failure. Throughout the task, which consists of blocks of 3 minutes, neuromuscular assessments will take place to determine the evolution of fatigability and its peripheral and central determinants.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Fatigability assessment

An isometric dynamometer will be used to assess fatigability development during a task to failure. Throughout the task, which consists of blocks of 3 minutes, neuromuscular assessments will take place to determine the evolution of fatigability and its peripheral and central determinants.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

Common for CP and healthy volunteers:

* Capable of walking for six minutes without stopping
* Capable of consenting to the tests

Specific for the CP group

* GMFCS I or II at age 18
* Spastic diplegic cerebral palsy

Exclusion Criteria

* Counter-indications to the test procedures
* Mental retardation or intelligence quotient (IQ) below 80
* Accompanying diseases not allowing for the test setup
* Major surgeries altering performance in the last six months
* Injection of botulin altering maximal force production in the last three months
* Refusing to sign the consent form

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes