Investigation of the Effects of Proprioceptive Neuromuscular Facilitation Exercises in Patients With Myasthenia Gravis

NCT ID: NCT06158815

Last Updated: 2025-07-15

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 23 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2022-12-28
• Study Completion Date: 2024-12-25

Brief Summary

The goal of this clinical trial is to investigate of the effects of proprioceptive neuromuscular facilitation exercises on fatigue, muscle strength and functional parameters in patient with Myasthenia Gravis. The main questions it aims to answer are:

• Do proprioceptive neuromuscular facilitation exercises reduce fatigue in patients with Myasthenia Gravis?
• Do proprioceptive neuromuscular facilitation exercises increase muscle strength in patients with Myasthenia Gravis?
• Do proprioceptive neuromuscular facilitation exercises improve functional parameters in patients with Myasthenia Gravis?
• How well can patients with Myasthenia Gravis tolerate proprioceptive neuromuscular facilitation exercises? Participants will be divided into 2 groups as control group and exercise group with block randomization method. In this single-blind randomized controlled study, the participants in the control group will be placed on a waiting list without any intervention during the 6-week study period and at the end of the study, the interventions applied to the exercise group will be applied exactly the same. Proprioceptive neuromuscular facilitation exercises will be applied to the exercise group 3 days a week, 1 hour a day for 6 weeks. Individuals will be evaluated at the beginning and at the end of the study.

Researchers will compare exercise and control group to see if there are effects of proprioceptive neuromuscular exercises patients with Myasthenia Gravis.

Conditions

Myasthenia Gravis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

control group

Participants in the control group will be placed on a waiting list without any intervention during the 6-week study period.

Group Type: NO_INTERVENTION

No interventions assigned to this group

exercise group

Participants in the exercise group will have face-to-face Proprioceptive Neuromuscular Facilitation Exercises during the 6-week study period.

Group Type: EXPERIMENTAL

proprioceptive neuromuscular facilitation exercise

Intervention Type: OTHER

The basic principle of Proprioceptive Neuromuscular Facilitation exercises, which is defined as facilitating the responses of the neuromuscular mechanism by stimulating the proprioceptors, is that the movements in the human body have a rotational and oblique character and that a greater response can be obtained with movement against maximum resistance. It is aimed to achieve improvement in strength and movement ability through hand contacts, visual and verbal stimuli.

Interventions

proprioceptive neuromuscular facilitation exercise

The basic principle of Proprioceptive Neuromuscular Facilitation exercises, which is defined as facilitating the responses of the neuromuscular mechanism by stimulating the proprioceptors, is that the movements in the human body have a rotational and oblique character and that a greater response can be obtained with movement against maximum resistance. It is aimed to achieve improvement in strength and movement ability through hand contacts, visual and verbal stimuli.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Volunteering to participate in the study
• Being between the ages of 18-65
• It must be confirmed by the Neurologist that the patient has been diagnosed with adult onset and Achr+ generalized Myasthenia Gravis and has been in a stable condition for the last 6 months.
• Being in class II or III according to the American Myasthenia Gravis Foundation Clinical Classification

Exclusion Criteria

• Having a cognitive problem or having a Mini Mental Test score below 24
• Change in the type and dose of medical treatment within the last 6 months
• Having another cardiorespiratory, metabolic, systemic, rheumatological, orthopaedic and neurological disease (unstable and at a level that prevents participation in the exercise programme) in addition to Myasthenia Gravis
• Having a body mass index below 17 kg/m2 and above 30 kg/m2
• Having participated in any physiotherapy program any intervention study for the last 6 months
• Having undergone pregnancy, birth or surgical operation in the last 6 months.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Hacettepe University

OTHER

Sponsor Role: lead

Responsible Party

ridvan muhammed adin

Master of Science, Research Assistant

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

sevim erdem özdamar, Professor

Role: PRINCIPAL_INVESTIGATOR

Hacettepe University

yeliz salcı, Assoc. Prof.

Role: STUDY_CHAIR

Hacettepe University

rıdvan m adın, M.Sc.

Role: STUDY_CHAIR

Hacettepe University

ayla fil balkan, Assoc. Prof.

Role: STUDY_CHAIR

Hacettepe University

Locations

Hacettepe University Faculty of Physical Therapy and Rehabilitation

Ankara, Altındag, Turkey (Türkiye)

Countries

Turkey (Türkiye)

Other Identifiers

KA-22017

Identifier Type: -

Identifier Source: org_study_id