Transcriptome Analysis of Human Bone Regeneration After Using an Anorganic Bovine Bone Graft With or Without a Combination of Polynucleotides and Hyaluronic Acid

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

5 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-09-04

Study Completion Date

2025-09-30

Brief Summary

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The goal of this clinical trial is to compare the expression of multiple genes related to bone regeneration in maxillary bone after being grafted with a commonly used biomaterial supplemented or not with a combination of hyaluronic acid and polynucleotides.

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Detailed Description

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Conditions

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Sinus Floor Augmentation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Anorganic bovine bone

Maxillary sinus floor augmentation grafted with anorganic bovine bone

Group Type ACTIVE_COMPARATOR

Maxillary sinus floor augmentation

Intervention Type PROCEDURE

Maxillary sinus floor augmentation through a lateral window grafted with anorganic bovine bone

Anorganic bovine bone + polynucleotides and hyaluronic acid

Maxillary sinus floor augmentation grafted with anorganic bovine bone + polynucleotides and hyaluronic acid

Group Type EXPERIMENTAL

Maxillary sinus floor augmentation

Intervention Type PROCEDURE

Maxillary sinus floor augmentation through a lateral window grafted with anorganic bovine bone + polynucleotides and hyaluronic acid

Interventions

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Maxillary sinus floor augmentation

Maxillary sinus floor augmentation through a lateral window grafted with anorganic bovine bone + polynucleotides and hyaluronic acid

Intervention Type PROCEDURE

Maxillary sinus floor augmentation

Maxillary sinus floor augmentation through a lateral window grafted with anorganic bovine bone

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Partially edentulous patients.
* Kennedy class I in the upper jaw.
* Less than 5 mm of residual crestal bone to the maxillary sinus.
* Need for the replacement of teeth with dental implants.

Exclusion Criteria

* Sinus pathology (sinusitis, mucocele, cysts).
* Smokers.
* Previous long-term (\>3 months) use of drugs known to affect bone metabolism, such as bisphosphonates.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No