Ventilation Imaging to Improve the Quality of Life for Patients With Lung Cancer Treated With Radiation Therapy

NCT ID: NCT06127654

Last Updated: 2025-04-04

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: PHASE3
• Total Enrollment: 165 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-05-31
• Study Completion Date: 2028-12-31

Brief Summary

This research project is testing a new treatment planning method for patients with lung cancer who will be treated with radiation therapy. This new method is called Computed Tomography (CT) ventilation imaging. It aims to help protect the healthiest parts of patient's lungs from being injured by the radiation therapy. The investigators will determine whether healthy lung sparing can improve the quality of life in these patients.

Detailed Description

The planning and delivery of Radiation Therapy (RT) is a balance between delivering a curative dose to the tumour while sparing healthy organs, such as the lungs, from collateral damage such as pneumonitis. To minimise radiation-induced lung injury, our team has invented and pioneered ventilation imaging based on Computed Tomography (CT). This Australian-invented medical device, now an international field of research, uses CT scans routinely acquired for planning RT to compute a CT ventilation map showing high functioning and low functioning lung regions. This image is used as the basis for directing radiation away from the healthy, high functioning regions towards the low functioning regions, thereby aiming to reduce toxicity and improve the patient's quality of life.

Conditions

Lung Cancer

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: QUADRUPLE

Study Groups

Intervention

Lung sparing treatment plan

Group Type: EXPERIMENTAL

Healthy lung sparing treatment plan

Intervention Type: DEVICE

CT Ventilation imaging will be used to create a healthy lung sparing treatment plan for patients who will receive radiation therapy treatment for their lung cancer.

Control

Standard treatment plan

Group Type: NO_INTERVENTION

No interventions assigned to this group

Interventions

Healthy lung sparing treatment plan

CT Ventilation imaging will be used to create a healthy lung sparing treatment plan for patients who will receive radiation therapy treatment for their lung cancer.

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

1. Aged 18 years or older.

2. Eastern Cooperative Oncology Group (ECOG) performance status 0-2.

3. Histologically proven non-small cell lung cancer.

4. Stage 3 as determined using the IASLC (International Association for the Study of Lung Cancer) 8th edition lung cancer staging guidelines.

5. To be treated with curative intent external beam radiotherapy (60 Gy in 30 treatments or 55 Gy in 20 treatments) +/- concurrent chemotherapy and adjuvant PD1/PD-L1 inhibitors.

6. Whole body Positron Emission Tomography (PET) scan within 8 weeks of registration.

7. Pulmonary function tests within 8 weeks of registration.

8. Willingness to give written informed consent.

9. Willingness to comply with the study procedures and visit requirements.

10. Available for follow up for a minimum of 12 months and up to 3 years.

1. Functional Assessment of Cancer Therapy - Lung (FACT-L) Trial Outcome Index (TOI) score of ≥5, the clinically meaningful difference

2. The standard treatment plan shows that at least 16% of volume of the lungs (minus the Gross Tumour Volume (GTV)) will receive more than 20 Gy. This criterion is based on the difference in pneumonitis risk between patients receiving below (~8%) and above (~34%) this threshold.

The QoL assessment is unlikely to eliminate any patients but is included for patients where no clinically meaningful difference will be possible. The treatment plan assessment may exclude 20% of otherwise eligible patients.

Exclusion Criteria

1. Serious medical comorbidities that may contraindicate curative radiotherapy.

2. Inability to attend full course of radiotherapy or follow-up visits.

3. A current or former diagnosis of interstitial lung disease.

4. Prior history of lung cancer within 5 years.

5. Prior thoracic radiotherapy at any time.

6. Prior surgery for this cancer within a year.

7. Prior chemotherapy for this cancer.

8. Pregnant or lactating women.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Liverpool Hospital

UNKNOWN

Sponsor Role: collaborator

Royal North Shore Hospital

OTHER

Sponsor Role: collaborator

The Alfred

OTHER

Sponsor Role: collaborator

Peter MacCallum Cancer Centre, Australia

OTHER

Sponsor Role: collaborator

Fundacion GenesisCare

NETWORK

Sponsor Role: collaborator

University of Sydney

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Paul Keall, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Sydney

Locations

Liverpool Hospital

Liverpool, New South Wales, Australia

Countries

Australia

Central Contacts

Shona Silvester

Role: CONTACT

shona.silvester@sydney.edu.au

+61413681368

Other Identifiers

IX-2022-CT-VITAL

Identifier Type: -

Identifier Source: org_study_id