Systems Oncology Approach to Optimize Ovarian Cancer Treatment

NCT ID: NCT06117384

Last Updated: 2023-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-01-01

Study Completion Date

2027-12-31

Brief Summary

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The overall aim is to identify effective therapeutic strategies to ovarian cancer (OC) using serial tumor, ascites and blood samples, and carry out state-of-the-art sequencing approaches, functional assays and associated bioinformatics to understand mechanisms behind chemoresistance in OC and identify new treatment options for OC patients. In this observational trial, we will systematically collect, analyze and interpret functional, molecular and clinical data from real-world ovarian cancer patients.

Detailed Description

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Conditions

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Ovarian Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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Biomolecular profiling

Molecular and functional analysis of biospecimens, including tumor-normal Whole-exome sequencing, bulk and single-cell RNAsequencing, spatial proteomics, functional testing.

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Patients diagnosed with ovarian cancer
* Available tumor tissue/blood samples

Exclusion Criteria

* Inability to consent to the study
Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Helsinki University Central Hospital

OTHER

Sponsor Role collaborator

University of Helsinki

OTHER

Sponsor Role lead

Responsible Party

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Anniina Färkkilä

Assistant Professor, Specialist in Gynecology

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Anniina Färkkilä, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Helsinki University Central Hospital

Locations

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Helsinki University and Helsinki University Hospital

Helsinki, , Finland

Site Status RECRUITING

Countries

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Finland

Central Contacts

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Anniina Färkkilä, MD PhD

Role: CONTACT

+358504272060

Facility Contacts

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Anniina Färkkilä, MD PhD

Role: primary

+358504272060

Other Identifiers

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HUS33342021

Identifier Type: -

Identifier Source: org_study_id

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