Effects of Cytotoxic Chemotherapy and PARP Inhibition on the Genomic Contexture of Ovarian Cancer

NCT ID: NCT04752865

Last Updated: 2023-03-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-02-09

Study Completion Date

2024-06-30

Brief Summary

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EFFECTS OF CYTOTOXIC CHEMOTHERAPY AND PARP INHIBITION ON THE GENOMIC CONTEXTURE OF OVARIAN CANCER: TR\_NACT\_OV/17 In order to approach the above open questions, ultimately aiming in understanding the effects of cancer drugs on tumor biology and hence in selecting the proper drugs for the patients in the context of Precision Medicine, the objective of this study is to study the genomic characteristics of ovarian tumors before and after treatment with classic neoadjuvant chemotherapy (NACT) and with the more recently approved PARP inhibitor olaparib.

Detailed Description

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Conditions

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Ovarian Cancer

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* ovarian cancer eligible for neoadjuvant chemotherapy

Exclusion Criteria

\-
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Hellenic Cooperative Oncology Group

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Adamantia Nikolaidi

Role: STUDY_CHAIR

HECOG

Locations

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Adamantia Nikolaidi

Athens, , Greece

Site Status RECRUITING

Countries

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Greece

Central Contacts

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Adamantia Nikolaidi, MD

Role: CONTACT

00302106912520 ext. 12

Maria Moschoni

Role: CONTACT

00302106912520 ext. 12

Facility Contacts

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Maria Moschoni

Role: primary

00302106912520 ext. 12

Other Identifiers

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TR_NACT_OV/17

Identifier Type: -

Identifier Source: org_study_id

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