PEPPI Study: Identification of Women at Risk for Placental Dysfunction

NCT ID: NCT06115122

Last Updated: 2025-08-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

3000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-02-15

Study Completion Date

2041-12-31

Brief Summary

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The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a Finnish general population.

Condition or disease: pre-eclampsia, intrauterine growth restriction, polycystic ovary syndrome

Detailed Description

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According to power calculations, altogether 3000 pregnant women will be recruited into PEPPI-study in Oulu area. Women will be recruited during their first visit to maternity care. Women will have blood samples for study purposes at first and third trimester of pregnancy. Participants will be divided into risk-, control- and polycystic ovary syndrome (PCOS) groups according to pre-eclampsia risk calculation program and questionnaire (PCOS: Rotterdam criteria) (N=300/group). Half of the women in risk- and control groups and all women in PCOS group will have a pregnancy ultrasound scan at 30-32 weeks of gestation. Fathers and children will be recruited at the Oulu University Hospital when the child is born.

Studies within PEPPI-study:

PEPPI-offspring: Children born for those 600 women in risk-, control and PCOS groups who have an extra ultrasound at gestational weeks 30-32 during PEPPI-study and children whose mother developed pre-eclampsia during the pregnancy regardless of her study group during PEPPI-study are recruited into PEPPI-offspring study. PEPPI-offspring study investigates the short- and long-term consequences of placental insufficiency/pre-eclampsia on the health of the children.

PEPPI-PCOS: Investigates pregnancy characteristics of women with PCOS. Women with PCOS form PCOS study group, have additional ultrasound scan at gestational weeks 30-32 and their children are recruited into PEPPI-offspring study.

FERPPI: FERPPI study investigates the possible connection between placental insufficiency and iron deficiency with or without anemia in both pregnant women and their children after birth.

Conditions

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Pre-Eclampsia Intrauterine Growth Restriction Polycystic Ovary Syndrome Iron-deficiency Cardiovascular Diseases Hypertensive Disorder of Pregnancy Proteinuria in Pregnancy

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Pre-eclampsia risk group

Approximately 300 women will be enrolled into a risk group according to a pre-eclampsia risk calculator.

Pre-eclampsia screening program

Intervention Type OTHER

Pregnant women will be devided into risk-, control- and PCOS groups according to first trimester screening program.

PCOS group

Women enrolled into study who fulfill ≥2 Rotterdam criteria. Women with PCOS may be included in risk- or control groups.

Pre-eclampsia screening program

Intervention Type OTHER

Pregnant women will be devided into risk-, control- and PCOS groups according to first trimester screening program.

Control group

Approximately 300 women in low risk for pre-eclampsia according to a pre-eclampsia risk calculator.

Pre-eclampsia screening program

Intervention Type OTHER

Pregnant women will be devided into risk-, control- and PCOS groups according to first trimester screening program.

Follow up group

Approximately 2100 women who are not enrolled into risk-, control- or PCOS groups.

Pre-eclampsia screening program

Intervention Type OTHER

Pregnant women will be devided into risk-, control- and PCOS groups according to first trimester screening program.

Children

Mothers and fathers will be asked for permission to follow the child's health information from national registers until the age of 15 years. Approximately 300 children will be recruited to PEPPI-offspring follow up study (including also PCOS offspring).

No interventions assigned to this group

Fathers

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No interventions assigned to this group

Interventions

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Pre-eclampsia screening program

Pregnant women will be devided into risk-, control- and PCOS groups according to first trimester screening program.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Pregnant (first trimester)
* Understands Finnish
* ≥18 years
* Signed informed consent


* Participates in PEPPI-study (criteria above)
* Blood samples at first and third trimester of pregnancy
* Permits blood sampling from the umbilical cord when the baby is born


* Biological father to the child born for the mother who participated in PEPPI study
* ≥18 years
* Signed informed consent


* Born to mother who participated in PEPPI study
* Signed informed consent from parent(s)



* Signed informed consent from parent(s)
* Mother has blood samples taken at first and third trimester (iron status)
* Child has blood samples taken at birth and at 3 months of age

Exclusion Criteria

* Multiple pregnancy
* Miscarriage/termination of the index pregnancy
* No first trimester blood sampling


* No first or third trimester blood sampling
* No umbilical cord blood sample after baby is born

Fathers


• Does not understand Finnish

Children


• No consent from parent(s)


• Mother/father declines participation


* No consent from parent(s)
* No blood samples from mother
* No blood samples from child
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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PerkinElmer, Inc.

INDUSTRY

Sponsor Role collaborator

Roche Diagnostics GmbH

INDUSTRY

Sponsor Role collaborator

Academy of Finland

OTHER

Sponsor Role collaborator

Sigrid Jusélius Foundation

OTHER

Sponsor Role collaborator

Finnish Medical Foundation

NETWORK

Sponsor Role collaborator

University of Oulu

OTHER

Sponsor Role collaborator

Oulu University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Jaana Nevalainen

Associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jaana Nevalainen, Assoc prof

Role: PRINCIPAL_INVESTIGATOR

The Wellbeing Services County of North Ostrobothnia

Locations

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The Wellbeing Services County of North Ostrobothnia

Oulu, , Finland

Site Status RECRUITING

Countries

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Finland

Central Contacts

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Jaana E Nevalainen, Assoc prof

Role: CONTACT

+358405801857

Terhi Piltonen, Professor

Role: CONTACT

+358405008266

Facility Contacts

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Jaana E Nevalainen, Assoc Prof

Role: primary

+358405801857

Terhi Piltonen, Professor

Role: backup

+358405008266

References

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Related Links

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http://www.peppitutkimus.fi

PEPPI-study's webpage

Other Identifiers

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OuluUH_PEPPI

Identifier Type: -

Identifier Source: org_study_id

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