Platform Assessing Regimens and Durations In a Global Multisite Consortium for TB
NCT ID: NCT06114628
Last Updated: 2025-10-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
PHASE2
2500 participants
INTERVENTIONAL
2024-01-09
2027-08-11
Brief Summary
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In the trial, two new drugs will be used, BTZ-043 and GSK3036656, along with the drugs that are already used to treat TB in a variety of combinations (11 different combinations initially). These new drugs have worked well in tests with animals and have reduced the amount of TB bacteria in people's sputum/phlegm when used alone for two weeks. These new drugs will be used in combination with other TB drugs for a longer time (up to 16 weeks) in people with TB. The UNITE4TB consortium want to see if they work well and are safe.
This trial will take place at sites across the world and will involve people with TB of the lungs that would usually respond well to the standard treatment. But the new treatments being tested might also work for people with drug resistant TB, that's harder to treat.
The trial has two parts. In the first part, different combinations of drugs will be tried on up to 700 people for 16 weeks. These combinations will be compared to the standard 24-week treatment to see which ones work the best and are safe.
In the second part, the best combinations from the first part will be taken to try to find out what the best length of time is to give the treatment for. These combinations will be tried on up to 1800 people giving them either 8, 10, 12, 14 or 16 weeks treatment. The investigators will follow these people for a total of 72 weeks to make sure the treatment is working.
The UNITE4TB consortium hope that this trial will find new treatments that are fast, safe, and effective for both regular TB and resistant TB. If it works, it can then be tested again in a bigger trial to be sure.
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Detailed Description
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This will be a randomised, open-label, multicentre, seamless phase 2B (regimen selection) and 2C (duration randomisation), multi-arm multi-stage, platform clinical trial
Overall objective:
The overall objective is to identify novel drug regimen(s) with acceptable safety profile, non-inferior efficacy, and shortened treatment duration compared to the standard-of-care 24-week HRZE/HR regimen (isoniazid + rifampicin + pyrazinamide + ethambutol for 8 weeks then isoniazid + rifampicin for 16 weeks) that could be used to treat both rifampicin-susceptible and resistant TB.
Specific sub-objectives:
The objective of the Phase 2B stage is to identify novel regimens of 16 weeks' duration with acceptable safety profile and the greatest potential, based on assessment of quantitative sputum liquid culture and treatment failure/relapse, to progress to investigation of optimal treatment duration
Amongst the regimens selected for progression from phase 2B to phase 2C stage, the objective is then to further evaluate the safety profile of these regimens and to identify the optimal treatment duration (between 8 and 16 weeks) based on unfavourable outcome to support advancement to future Phase 3 trials.
Setting:
Specialist TB clinics and research centres in sites across Europe, Asia, Africa and South America
Population:
Adults with newly diagnosed, rifampicin-susceptible pulmonary TB
Duration:
Individual participant participation will be for 72 weeks. The total duration of trial is 5 years.
Interventions:
Phase 2B: Participants will be randomised (1:1:1..1) to the following 12 arms (A-L) initially. Additional arms maybe added through protocol amendment.
Control, standard-of-care regimen, given for 24 weeks
A. Isoniazid + rifampicin + pyrazinamide + ethambutol for 8 weeks then isoniazid + rifampicin for 16 weeks
Novel treatment regimens each given for 16 weeks
B. Bedaquiline + delamanid + moxifloxacin
C. Bedaquiline + delamanid + moxifloxacin + GSK306656
D. Bedaquiline + delamanid + pyrazinamide + GSK306656
E. Bedaquiline + delamanid + linezolid (for first 8 weeks) + GSK306656
F. Bedaquiline + pretomanid + moxifloxacin + GSK306656
G. Bedaquiline + delamanid + moxifloxacin + BTZ-043
H. Bedaquiline + delamanid + pyrazinamide + BTZ-043
I. Bedaquiline + delamanid + linezolid (for first 8 weeks) + BTZ-043
J. Bedaquiline + pretomanid + moxifloxacin + BTZ-043
K. Bedaquiline + moxifloxacin + pyrazinamide + BTZ-043
L. Bedaquiline + delamanid + GSK306656 + BTZ-043
There are two planned interim analyses of safety and efficacy data by an Independent Data Monitoring Committee in Phase 2B. The first interim analysis will occur when the last participant for arms to be included in the analysis, completes 16 weeks of treatment and all necessary data are available. The second interim analysis will occur when the last participant for arms to be included in the analysis completes to week 48 (from randomisation) and all necessary data are available. The IDMC will make recommendation to the Trial Steering Committee (TSC) and Asset Holders on the progression of regimens to Phase 2C. The TSC will make the final decision. Arm B (bedaquiline + delamanid + moxifloxacin) will not be considered for progression to 2C.
Phase 2C:
For regimens selected for progression (following interim phase 2B evaluation). Participants will be randomised to treatment durations of either 8 weeks, 10 weeks, 12 weeks, 14 weeks, 16 weeks or to the 24-week standard-of-care regimen (as described above).
Primary Efficacy Outcome Measure(s) -
Phase 2B: rate of change in log10(TTP) over 0 to 12 weeks, where TTP is time to positivity measured in days from MGIT culture
Phase 2C: Favourable/unfavourable status (binary) at week 48 from randomisation
Safety Outcome Measures (Phase 2B and 2C) -
The following outcomes will be reported up to week 26 from randomisation (unless otherwise stated):
* Grade 3/4/5 adverse events (DAIDS grading scale)
* Serious Adverse Events
* Adverse Events of Special Interest
* Regimen-related adverse events leading to withdrawal from the study
* Adverse events leading to discontinuation of the regimen
Number of Participants to be Studied:
Up to 2500 overall - 700 in phase 2B and 1800 in phase 2C (distribution between phases depends on progression according to specified decision-making steps)
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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A. Standard TB Regimen. 2HRZE/4HR
24 weeks treatment in both Phase 2B and 2C - 8 weeks Rifampicin, Isoniazid, Pyrazinamide, Ethambutol followed by 16 weeks Rifampicin and Isoniazid.
Pyrazinamide (Z)
Oral daily dosage of 1200mg-2000mg depending on weight.
Rifampicin (R)
Oral daily dosage of 450mg-750mg depending on weight.
Isoniazid (H)
Oral daily dosage of 225mg-375mg depending on weight.
Ethambutol (E)
Oral daily dosage of 825mg-1375mg depending on weight.
Arm B. BDM
Bedaquiline, Delamanid, Moxifloxacin for 16 weeks in Phase 2B
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Delamanid (D)
Oral daily dosage of 300mg.
Moxifloxacin (M)
Oral daily dosage of 400mg.
Arm C. BDM + Gan
Bedaquiline, Delamanid, Moxifloxacin and Ganfeborole for 16 weeks in Phase 2B Bedaquiline, Delamanid, Moxifloxacin and Ganfeborole for 8-16 weeks in phase 2C
Ganfeborole
Oral daily dosage of 20mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Delamanid (D)
Oral daily dosage of 300mg.
Moxifloxacin (M)
Oral daily dosage of 400mg.
Arm D. BDZ + Gan
Bedaquiline, Delamanid, Pyrazinamide and Ganfeborole for 16 weeks in Phase 2B Bedaquiline, Delamanid, Pyrazinamide and Ganfeborole for 8-16 weeks in phase 2C
Ganfeborole
Oral daily dosage of 20mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Delamanid (D)
Oral daily dosage of 300mg.
Pyrazinamide (Z)
Oral daily dosage of 1200mg-2000mg depending on weight.
Arm E. BDL + 656
Bedaquiline, Delamanid, Linezolid and Ganfeborole for 8 weeks followed by 8 weeks Bedaquiline, Delamanid and Ganfeborole in Phase 2B Bedaquiline, Delamanid, Linezolid and Ganfeborole for 8 weeks followed by 0-8 weeks Bedaquiline, Delamanid and Ganfeborole in Phase 2C
Ganfeborole
Oral daily dosage of 20mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Delamanid (D)
Oral daily dosage of 300mg.
Linezolid (L)
Oral daily dosage of 600mg for the first 8 weeks.
Arm F. BPaM + Gan
Bedaquiline, Pretomanid, Moxifloxacin and Ganfeborole for 16 weeks in Phase 2B Bedaquiline, Pretomanid, Moxifloxacin and Ganfeborolefor 8-16 weeks in Phase 2C
Ganfeborole
Oral daily dosage of 20mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Pretomanid (Pa)
Oral daily dosage of 200mg.
Moxifloxacin (M)
Oral daily dosage of 400mg.
Arm G. BDM + BTZ-043
Bedaquiline, Delamanid, Moxifloxacin and BTZ-043 for 16 weeks in Phase 2B Bedaquiline, Delamanid, Moxifloxacin and BTZ-043 for 8-16 weeks in phase 2C
BTZ-043
Oral daily dosage of 1000mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Delamanid (D)
Oral daily dosage of 300mg.
Moxifloxacin (M)
Oral daily dosage of 400mg.
Arm H. BDZ + BTZ-043
Bedaquiline, Delamanid, Pyrazinamide and BTZ-043 for 16 weeks in Phase 2B Bedaquiline, Delamanid, Pyrazinamide and BTZ-043 for 8-16 weeks in phase 2C
BTZ-043
Oral daily dosage of 1000mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Delamanid (D)
Oral daily dosage of 300mg.
Pyrazinamide (Z)
Oral daily dosage of 1200mg-2000mg depending on weight.
Arm I. BDL + BTZ-043
Bedaquiline, Delamanid, Linezolid and BTZ-043 for 8 weeks followed by 8 weeks Bedaquiline, Delamanid and BTZ-043 in Phase 2B Bedaquiline, Delamanid, Linezolid and BTZ-043 for 8 weeks followed by 0-8 weeks Bedaquiline, Delamanid and BTZ-043 in Phase 2C
BTZ-043
Oral daily dosage of 1000mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Delamanid (D)
Oral daily dosage of 300mg.
Linezolid (L)
Oral daily dosage of 600mg for the first 8 weeks.
Arm J. BPaM + BTZ-043
Bedaquiline, Pretomanid, Moxifloxacin and BTZ-043 for 16 weeks in Phase 2B Bedaquiline, Pretomanid, Moxifloxacin and BTZ-043 for 8-16 weeks in Phase 2C
BTZ-043
Oral daily dosage of 1000mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Pretomanid (Pa)
Oral daily dosage of 200mg.
Moxifloxacin (M)
Oral daily dosage of 400mg.
Arm K. BMZ + BTZ-043
Bedaquiline, Moxifloxacin, Pyrazinamide and BTZ-043 for 16 weeks in Phase 2B Bedaquiline, Moxifloxacin, Pyrazinamide and BTZ-043 for 8-16 weeks in phase 2C
BTZ-043
Oral daily dosage of 1000mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Moxifloxacin (M)
Oral daily dosage of 400mg.
Pyrazinamide (Z)
Oral daily dosage of 1200mg-2000mg depending on weight.
Arm L. BD + Gan + BTZ-043
Bedaquiline, Delamanid, Ganfeborole and BTZ-043 for 16 weeks in Phase 2B Bedaquiline, Delamanid, Ganfeborole and BTZ-043 for 8-16 weeks in phase 2C
Ganfeborole
Oral daily dosage of 20mg.
BTZ-043
Oral daily dosage of 1000mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Delamanid (D)
Oral daily dosage of 300mg.
Arm M: BDM + Q
Bedaquiline, delamanid, moxifloxacin, quabodepistat for 16 weeks in Phase 2B
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Delamanid (D)
Oral daily dosage of 300mg.
Moxifloxacin (M)
Oral daily dosage of 400mg.
Quabodepistat (Q)
Oral daily dosage of 30mg
Arm N: BPAM + Q
Bedaquiline, pretomanid, moxifloxacin, quabodepistat for 16 weeks in Phase 2B
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Pretomanid (Pa)
Oral daily dosage of 200mg.
Moxifloxacin (M)
Oral daily dosage of 400mg.
Quabodepistat (Q)
Oral daily dosage of 30mg
Arm O: BD + Gan + Q
Bedaquiline, delamanid, ganfeborole, quabodepistat for 16 weeks in Phase 2B
Ganfeborole
Oral daily dosage of 20mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Delamanid (D)
Oral daily dosage of 300mg.
Quabodepistat (Q)
Oral daily dosage of 30mg
Arm P: BPa + Gan +Q
Bedaquiline, pretomanid, ganfeborole, quabodepistat for 16 weeks in Phase 2B
Ganfeborole
Oral daily dosage of 20mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Pretomanid (Pa)
Oral daily dosage of 200mg.
Quabodepistat (Q)
Oral daily dosage of 30mg
Arm Q: BPa + DZD + BTZ-043
Bedaquiline, pretomanid, delpazolid, BTZ-043 for 16 weeks in Phase 2B
BTZ-043
Oral daily dosage of 1000mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Pretomanid (Pa)
Oral daily dosage of 200mg.
Delpazolid (DZD)
Oral daily dosage of 1200mg
Interventions
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Ganfeborole
Oral daily dosage of 20mg.
BTZ-043
Oral daily dosage of 1000mg.
Bedaquiline (B)
Oral daily dosage of 400mg for the first 2 weeks, thereafter 100mg daily until end of treatment.
Delamanid (D)
Oral daily dosage of 300mg.
Pretomanid (Pa)
Oral daily dosage of 200mg.
Moxifloxacin (M)
Oral daily dosage of 400mg.
Linezolid (L)
Oral daily dosage of 600mg for the first 8 weeks.
Pyrazinamide (Z)
Oral daily dosage of 1200mg-2000mg depending on weight.
Rifampicin (R)
Oral daily dosage of 450mg-750mg depending on weight.
Isoniazid (H)
Oral daily dosage of 225mg-375mg depending on weight.
Ethambutol (E)
Oral daily dosage of 825mg-1375mg depending on weight.
Delpazolid (DZD)
Oral daily dosage of 1200mg
Quabodepistat (Q)
Oral daily dosage of 30mg
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
2. Clinical evidence of active TB disease, meeting either or both of the following criteria:
* Symptoms consistent with pulmonary TB at screening AND/OR
* Imaging findings consistent with active pulmonary TB on chest X-ray performed at screening or within 7 days prior to screening
3. At least one sputum specimen produced at screening tested on Xpert MTB/RIF Ultra that has:
* a semi-quantitative result of 'medium' or 'high' AND
* does not show rifampicin resistance
4. Body weight within the range of 30 to 100kg and body mass index within the range of 15 to 40kg/m2
5. Willing to comply with study visits, all study procedures and treatment observation
6. Resident at a fixed address that is readily accessible for visiting, within feasible travelling distance to the site and likely to remain resident there for the duration of trial follow-up
7. Has provided written informed consent
Exclusion Criteria
2. Known isoniazid resistance (at sites where national isoniazid monoresistance is greater than 10% rapid testing at screening is mandated; at other sites rapid testing at screening is optional)
3. Known or suspected extra-thoracic TB, miliary TB or disseminated TB (in the judgement of the investigator; note uncomplicated pleural effusion occupying \<50% of hemithorax or concomitant intra- or extra-thoracic lymphadenopathy are not exclusions)
4. Severe clinical pulmonary TB e.g. respiratory failure or complications likely to require hospital admission in the opinion of the investigator
5. Poor general condition (Karnofsky score ≤50) OR where any delay in treatment cannot be tolerated in the opinion of the investigator
6. Active malignancy requiring systemic therapy, radiotherapy or palliative therapy
7. History of myocardial infarction, coronary heart disease or congestive cardiac failure; long QT syndrome or clinically significant arrhythmias; pulmonary hypertension; any known congenital cardiac problems; family history of long QT syndrome or sudden death from unknown or cardiac related cause; uncontrolled arterial hypertension (not excluded if this is corrected prior to randomisation)
8. Vitiligo
9. History of seizure(s)
10. Current tendinitis (any cause) or history of tendinopathy associated with fluoroquinolone use
11. History of vascular aneurysm
12. Symptomatic peripheral neuropathy causing greater than minimal interference with usual social and functional activities
13. Current alcohol or illicit drug use sufficient to compromise the safety of the participant or research staff or compromise adherence to study procedures, in the opinion of the investigator
14. Any current or recent use of amphetamines or methamphetamines, either reported or evident on toxicity screen, if performed
15. Any other medically or socially significant condition (e.g. psychiatric illness, chronic diarrhoeal disease, metabolic condition, other cardiovascular disease not listed under criterion 7), that would, in the opinion of the investigator, compromise the participant's safety or outcome in the trial; or lead to poor compliance with study visits and protocol requirements; or compromise the interpretation of trial safety and efficacy endpoints
16. Women who are currently pregnant or breast-feeding
17. Women of childbearing potential unwilling or unable to use appropriate effective contraception during the study intervention period and for at least 14 days after the last dose of study intervention; and unwilling to commit to refrain from donating eggs (ova, oocytes) for the purpose of reproduction during this period; definitions of childbearing potential and appropriate effective contraception given below\*\*
18. Men who are unwilling to use a condom during the study period and for at least 90 days after the last dose of study drug during any activity that allows for the passage of ejaculate to another person; and are unwilling to commit to refrain from donating fresh unwashed semen
19. Known allergy to one or more of the study drugs
20. Taking a concomitant medication that has a known or predicted interaction with any of the study drugs to which the participant might be randomised. The participant need not be excluded if:
1. the concomitant medication can be stopped or replaced with an alternative non-interacting medication, if needed AND
2. the investigator judges there to be no residual clinical risk to the participant after stopping the concomitant medication (taking into account the washout period of 5x the half-life of the concomitant medication and the duration of the effect of the interaction on levels of study medication)
21. Taking a concomitant medication that is known to prolong the QTc interval. The participant need not be excluded if the concomitant medication can be stopped or replaced with an alternative medication, if needed, and the duration of the QTc prolongation is expected to resolve prior to dosing of study medication (taking into account the washout period of 5x the half-life of the concomitant medication)
22. Treatment with any immunosuppressive drugs within the 2 weeks prior to screening (taking systemic corticosteroids for less than 5 consecutive days and stopped at or prior to screening are not an exclusion; topical or inhaled steroids that are taken at a dose below the threshold considered to have systemic immunosuppressive effects are not excluded)
23. Participation in other clinical intervention trial with an investigational agent within 8 weeks prior to the first dosing day in this trial
24. 12-lead ECGs at screening or at baseline shows QTcF \>450ms (men) or \>460ms (women) calculated by Fridericia's formula; and/or any other clinically significant abnormality such as arrhythmia or ischaemia
25. Any of the following laboratory parameters at screening:
1. Haemoglobin \< 9g/dl
2. Platelet count \< 50 x 109 cells/L
3. Absolute neutrophil count \<1000 cells/μL
4. Creatinine clearance of \<75ml/min, calculated using Cockcroft-Gault equation\*
5. ALT or AST \> 3 times the upper limit of normal
6. Total bilirubin \> 1.5 times upper limit of normal
7. Serum potassium \<3.5 mmol/L (not excluded if corrected to above this level)
8. Serum magnesium \< 0.70mmol/L (not excluded if corrected to above this level)
9. Serum calcium (corrected for albumin level) \< 2.10 mmol/L (not excluded if corrected to above this level)
26. Hepatitis B surface antigen positive (known, or on a test performed at screening)
27. HIV antibody positive (known, or on test performed at screening)\*
28. Known Hepatitis C virus infection (unless also known to have negative PCR test)\*
18 Years
ALL
No
Sponsors
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Radboud University Medical Center
OTHER
London School of Hygiene and Tropical Medicine
OTHER
University of Oxford
OTHER
Research Center Borstel
OTHER
Lygature
UNKNOWN
TASK Applied Science
OTHER
Vita-Salute San Raffaele University
UNKNOWN
Helmholtz Zentrum Munchen
UNKNOWN
KNCV Tuberculosis Foundation
OTHER
Critical Path Institute
UNKNOWN
European Lung Foundation
UNKNOWN
Instituto de Saude Publica da Universidade do Porto
OTHER
University of Liverpool
OTHER
Institut de Recherche pour le Developpement
OTHER_GOV
University of Hamburg-Eppendorf
OTHER
University of California, San Francisco
OTHER
TB Alliance
UNKNOWN
Find
OTHER
University of Milano
UNKNOWN
University of St Andrews
OTHER
Uppsala University
OTHER
European Respiratory Society
OTHER
Tuberculosis Network European Trialsgroup
NETWORK
Janssen, LP
INDUSTRY
Otsuka Pharmaceutical Development & Commercialization, Inc.
INDUSTRY
German Center for Infection Research
OTHER
LMU University Hospital Munich
UNKNOWN
University of Cambridge
OTHER
GlaxoSmithKline
INDUSTRY
University College, London
OTHER
Responsible Party
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Locations
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PMSI Institute of Pneumology "Chiril Draganiuc"
Chisinau, , Moldova
TASK Brooklyn
Cape Town, , South Africa
University of Cape Town Lung Institute
Cape Town, , South Africa
TASK Eden
George, , South Africa
NIMR Mbeya
Mbeya, , Tanzania
Kibong'oto Infectious Diseases Hospital
Moshi, , Tanzania
NIMR Mwanza
Mwanza, , Tanzania
Joint Clinical Research Centre
Kampala, , Uganda
Makerere University Lung Institute
Kampala, , Uganda
National Lung Hospital
Hanoi, , Vietnam
Pnth/Oucru
Ho Chi Minh City, , Vietnam
Countries
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Central Contacts
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Facility Contacts
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Fairoez Ryklief
Role: primary
Rodney Dawson
Role: primary
Louis Botha
Role: primary
Lilian Tina Minja
Role: primary
Stellah Mpagama
Role: primary
Kidola Jeremiah
Role: primary
Cissy Kityo Mutuluuza
Role: primary
Bruce Kirenga
Role: primary
References
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Eckhardt E, Li Y, Mamerow S, Schinkothe J, Sehl-Ewert J, Dreisbach J, Corleis B, Dorhoi A, Teifke J, Menge C, Kloss F, Bastian M. Pharmacokinetics and Efficacy of the Benzothiazinone BTZ-043 against Tuberculous Mycobacteria inside Granulomas in the Guinea Pig Model. Antimicrob Agents Chemother. 2023 Apr 18;67(4):e0143822. doi: 10.1128/aac.01438-22. Epub 2023 Mar 28.
Tenero D, Derimanov G, Carlton A, Tonkyn J, Davies M, Cozens S, Gresham S, Gaudion A, Puri A, Muliaditan M, Rullas-Trincado J, Mendoza-Losana A, Skingsley A, Barros-Aguirre D. First-Time-in-Human Study and Prediction of Early Bactericidal Activity for GSK3036656, a Potent Leucyl-tRNA Synthetase Inhibitor for Tuberculosis Treatment. Antimicrob Agents Chemother. 2019 Jul 25;63(8):e00240-19. doi: 10.1128/AAC.00240-19. Print 2019 Aug.
Li X, Hernandez V, Rock FL, Choi W, Mak YSL, Mohan M, Mao W, Zhou Y, Easom EE, Plattner JJ, Zou W, Perez-Herran E, Giordano I, Mendoza-Losana A, Alemparte C, Rullas J, Angulo-Barturen I, Crouch S, Ortega F, Barros D, Alley MRK. Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). J Med Chem. 2017 Oct 12;60(19):8011-8026. doi: 10.1021/acs.jmedchem.7b00631. Epub 2017 Sep 27.
Other Identifiers
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UNITE4TB-01
Identifier Type: -
Identifier Source: org_study_id
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