Outcomes and Predictors of Mortality Among Preterm Infants With Neonatal Sepsis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-10-28

Study Completion Date

2025-03-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

A prospective cross-sectional study of outcomes and predictors of mortality among preterm infants with neonatal sepsis admitted in NICU of Assiut University Children's Hospital

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Clinical Criteria for a Pathogen in Term Newborn Suspected of Neonatal Sepsis

NCT03623503

Newborn Sepsis

COMPLETED

Microfluidic Assessment of Clinical Outcomes in Preterm Newborns

NCT03291496

Neonatal SEPSIS

ACTIVE_NOT_RECRUITING

Improved Detection of Neonatal Sepsis Using a Targeted Biomarker Assay

NCT01120678

Neonatal Sepsis

COMPLETED

Predictors of Sepsis in Ex-Preterm Infants

NCT03433846

Sepsis Premature Birth

COMPLETED

Novel Mechanisms and Approaches to Treat Neonatal Sepsis

NCT02554630

Complication of Prematurity Immunologic Deficiency Syndromes

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Neonatal sepsis is a clinical syndrome of bacteremia with systemic signs and symptoms of infection in the first 28 days of life. It can also result from viral and fungal invasions of the bloodstream It is one of the events that can occur during neonatal intensive care unit (NICU) admission. It contributes significantly to the morbidity of very preterm (VP: \<32 weeks gestational age) and/or very low birthweight (VLBW: \<1500 g) infants Sepsis is a major cause of neonatal mortality and neurodevelopmental impairment among neonates which results in death and major disability for 39% of those affected even with timely antibiotic treatment .

Globally, it is estimated that more than 1.4 million neonatal deaths annually are the consequence of invasive infections .

Infection-specific mortality varies by geographic region and neonatal risk factors like gestational age and body weight .

It contributes to nearly 30-50% of neonatal deaths in developing countries . The risk of death is highest in the first 24 h of life when more than half of deaths occur and about three-quarters of all neonatal deaths occur within the first week of life.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Neonatal Sepsis

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Prospective study

Prospective study of outcomes and predictors of mortality among preterm infants with neonatal sepsis

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* All preterm infants (\<37 weeks) diagnosed with neonatal sepsis
* Preterm infants aged 0-28 days

Exclusion Criteria

* Full term infants (\> 37 weeks gestation) -Neonates with congenital anomalies -Neonates diagnosed with metabolic diseases
* Neonates with birth asphyxia

Minimum Eligible Age

1 Minute

Maximum Eligible Age

28 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

No