Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
555 participants
OBSERVATIONAL
2020-03-01
2021-05-01
Brief Summary
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Primary Objective Report the rates of serious and invasive bacterial infections in febrile infants
Secondary Objectives Report on the predictive value of different clinical features for predicting bacterial infections.
Report on the value of biomarkers for predicting serious and invasive bacterial infections.
Assess the performance of clinical practice guidelines for the assessment of febrile infants.
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Detailed Description
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We intend to assess the current approach to febrile infants and compare that to the available clinical practice guidelines. We also intend to determine which clinical and/or laboratory features are most predictive of serious bacterial infection.
Conditions
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Group 1
All infants aged 0-90 days (inclusive) undergoing routine assessments for fever without source.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
90 Days
ALL
No
Sponsors
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Bristol Royal Hospital for Children
OTHER
University Hospitals, Leicester
OTHER
Barts & The London NHS Trust
OTHER
Children's Health Ireland
OTHER_GOV
Royal Hospital for Children Glasgow
UNKNOWN
Royal Belfast Hospital for Sick Children
UNKNOWN
Belfast Health and Social Care Trust
OTHER
Responsible Party
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Thomas Waterfield
Doctor
Locations
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Children's Health Ireland
Dublin, , Ireland
Royal Belfast Hospital for Sick Children
Belfast, Northern Ireland, United Kingdom
Bristol Royal Children's Hospital
Bristol, , United Kingdom
Royal Hospital for Children Glasgow
Glasgow, , United Kingdom
Leicester Royal Infirmary
Leicester, , United Kingdom
Royal London Hospital
London, , United Kingdom
Countries
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References
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Waterfield T, Foster S, Platt R, Barrett MJ, Durnin S, Maney JA, Roland D, McFetridge L, Mitchell H, Umana E, Lyttle MD; Paediatric Emergency Research in the UK and Ireland (PERUKI). Diagnostic test accuracy of dipstick urinalysis for diagnosing urinary tract infection in febrile infants attending the emergency department. Arch Dis Child. 2022 Dec;107(12):1095-1099. doi: 10.1136/archdischild-2022-324300. Epub 2022 Aug 24.
Waterfield T, Lyttle MD, Munday C, Foster S, McNulty M, Platt R, Barrett M, Rogers E, Durnin S, Jameel N, Maney JA, McGinn C, McFetridge L, Mitchell H, Puthucode D, Roland D; Paediatric Emergency Research in the UK and Ireland (PERUKI). Validating clinical practice guidelines for the management of febrile infants presenting to the emergency department in the UK and Ireland. Arch Dis Child. 2022 Apr;107(4):329-334. doi: 10.1136/archdischild-2021-322586. Epub 2021 Sep 16.
Other Identifiers
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QIP10/12/19HJ
Identifier Type: -
Identifier Source: org_study_id
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