Quantitative Assessment of Lid Margin Vascularity Using SS-OCTA

NCT ID: NCT06091722

Last Updated: 2023-10-19

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 150 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-10-20
• Study Completion Date: 2024-02-28

Brief Summary

To explore an optimized scan technique for the detection of lid margin vasculature

Detailed Description

To investigate whether the SS-OCTA tool has the potential to characterize the lid margin vascularity in MGD patients. The repeatability and validity of OCTA in assessing eyelid margin blood flow density was evaluated。

Conditions

Ss-octa; Lid Margin Blood Flow Density; MGD

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

1

Mild group, the scores of both clinicians were ≤ grade 1

No interventions assigned to this group

2

Moderate group, one doctor scored grade 2, and the other doctor scored 1\~2;

No interventions assigned to this group

3

Moderate group, one doctor scored grade 2, and the other doctor scored 1\~2;

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

The MGD patients were aged >_20 years and were diagnosed according to Chinese MGD diagnostic criteria,11 including dry eye symptoms, and at least one of the following signs: (1) poor meibum expressibility or quality; (2) at least one of eyelid margin abnormalities (lid margin irregularity, plugging of the gland orifice, vascular engorgement/telangiectasia, and anterior replacement of the mucocutaneous junction. Normal subjects were defined as adults without any dry eye symptoms and lid margin abnormality.

Exclusion Criteria

(1) subjects with ocular diseases or conditions known to affect the anatomy of the anterior segment, such as acute ocular inflammation, a history of eyelid surgery, contact lens wear within two weeks, and/or eyelid trauma; (2) subjects with of history of systemic or topical medications that might cause ocular congestion; (3) subjects with severe systemic illness or pregnancy; and (4) subjects who were difficult to cooperate with examination, resulting the obtained images were not sufficiently clear for automatic analysis.

• Minimum Eligible Age: 20 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Wenzhou Medical University

OTHER

Sponsor Role: lead

Responsible Party

Yune Zhao

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Man HU

Role: CONTACT

64344308@qq.com

13738069080

Other Identifiers

20230801LMBFD

Identifier Type: -

Identifier Source: org_study_id