Biological Implications of the Overlapping Phenomenon Between Childhood Schizophrenia and Autism Spectrum Disorders-Heterogeneity Approach Rather Than Diagnostic Boundary

NCT ID: NCT06063525

Last Updated: 2023-10-18

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 230 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2015-02-02
• Study Completion Date: 2024-12-31

Brief Summary

Complex diseases such as schizophrenia and autism are heterogeneous in clinical presentation and etiology. This high heterogeneity constitutes the challenges for the clinical diagnosis and etiological research, resulting in that the majority of research findings cannot be replicated in the independent samples. For the high comorbid rate between the diagnoses of schizophrenia and autism spectrum disorders (ASD), and the shared neurocognitive deficits, genetic risks, and biological markers between the two disorders, a heterogeneity approach may probably be more promising than to arbitrarily split the two diagnostic categories apart or lump them together for etiological research. In schizophrenia, patients with a very early onset of disease and with preceding neurodevelopmental conditions may imply a different underlying etiology from those with typical onset and without neurodevelopmental conditions. Echoing the evidence that in early onset Parkinson's disease, PARK2 (encoding parkin protein) mutations are successfully reported to be as frequent as 49% with an autosomal-recessive mode of inheritance , representing a specific disease entity of Parkinson's disease. Therefore, it is critical to characterize the clinical phenotypes for this subpopulation of very early onset patients, including their clinical manifestation, disease course, and treatment response, as well as early developmental history and morphological characteristics. These may establish an important base for investigating the etiology and providing adequate clinical care for the heterogeneous syndrome of schizophrenia

Conditions

Schizophrenia; Autism Spectrum Disorder

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

childhood onset schizophrenia (COS)

diagnosis of schizophrenia under the age of 13 years.

Structural anatomy

Intervention Type: OTHER

images acquired with 3T MRI system with 32 channel head coil

schizophrenia (SZ)

patients with schizophrenia with and age of onset later than 13 years

Structural anatomy

Intervention Type: OTHER

images acquired with 3T MRI system with 32 channel head coil

autism spectrum disorder (ASD)

dual diagnosis of schizophrenia and ASD, including SZ with ASD, COS with ASD

Structural anatomy

Intervention Type: OTHER

images acquired with 3T MRI system with 32 channel head coil

Interventions

Structural anatomy

images acquired with 3T MRI system with 32 channel head coil

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• SZ group: schizophrenia onset earlier than 12 years old
• COS group: schizophrenia onset later than 12 years old
• ASD group: diagnosed with autism spectrum disorder without schizophrenia
• Dual group: diagnosed with ASD and SZ

Exclusion Criteria

• congenital disease
• major physical diseases
• neurodegenerative disorder
• chromosomal aberration

• Minimum Eligible Age: 15 Years
• Maximum Eligible Age: 59 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Taiwan University Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Other Identifiers

201412165RINB

Identifier Type: -

Identifier Source: org_study_id