A Study to Evaluate the Efficacy and Safety of AD-223

NCT ID: NCT06052748

Last Updated: 2025-04-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

502 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-02-15

Study Completion Date

2025-04-02

Brief Summary

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The purpose of this study is to evaluate the efficacy and safety of AD-223

Detailed Description

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Condition or disease : hypertension

Conditions

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Hypertension,Essential

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Test group

AD-223A+AD-223B+AD-223C Placebo

Group Type EXPERIMENTAL

AD-223A

Intervention Type DRUG

PO, Once daily(QD), 8weeks

AD-223B

Intervention Type DRUG

PO, Once daily(QD), 8weeks

AD-223C Placebo

Intervention Type DRUG

PO, Once daily(QD), 8weeks

Control group 1

AD-223A+AD-223B Placebo+AD-223C Placebo

Group Type ACTIVE_COMPARATOR

AD-223A

Intervention Type DRUG

PO, Once daily(QD), 8weeks

AD-223B Placebo

Intervention Type DRUG

PO, Once daily(QD), 8weeks

AD-223C Placebo

Intervention Type DRUG

PO, Once daily(QD), 8weeks

Control group 2

AD-223A Placebo+AD-223B+AD-223C Placebo

Group Type ACTIVE_COMPARATOR

AD-223B

Intervention Type DRUG

PO, Once daily(QD), 8weeks

AD-223A Placebo

Intervention Type DRUG

PO, Once daily(QD), 8weeks

AD-223C Placebo

Intervention Type DRUG

PO, Once daily(QD), 8weeks

Control group 3

AD-223A Placebo+AD-223B Placebo+AD-223C

Group Type ACTIVE_COMPARATOR

AD-223C

Intervention Type DRUG

PO, Once daily(QD), 8weeks

AD-223A Placebo

Intervention Type DRUG

PO, Once daily(QD), 8weeks

AD-223B Placebo

Intervention Type DRUG

PO, Once daily(QD), 8weeks

Interventions

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AD-223A

PO, Once daily(QD), 8weeks

Intervention Type DRUG

AD-223B

PO, Once daily(QD), 8weeks

Intervention Type DRUG

AD-223C

PO, Once daily(QD), 8weeks

Intervention Type DRUG

AD-223A Placebo

PO, Once daily(QD), 8weeks

Intervention Type DRUG

AD-223B Placebo

PO, Once daily(QD), 8weeks

Intervention Type DRUG

AD-223C Placebo

PO, Once daily(QD), 8weeks

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Signed informed consent
* Other inclusions applied

Exclusion Criteria

* Orthostatic hypotension with symptom
* Other exclusions applied
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Addpharma Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jin Ho Shin, M.D., Ph.D

Role: PRINCIPAL_INVESTIGATOR

Hanyang University

Locations

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Hanyang University Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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AD-223P3

Identifier Type: -

Identifier Source: org_study_id

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