Diagnostic Importance of the C-reactive Protein From Blood and Saliva in Children With Acute Appendicitis

NCT ID: NCT06051825

Last Updated: 2023-09-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-11-01

Study Completion Date

2024-11-30

Brief Summary

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Diagnosing acute appendicitis in children is still a challenge even for experienced clinicians. Failure to recognize this acute condition can result in perforation, with consequent peritonitis, or misdiagnosis can result in negative appendectomies. C-reactive protein in blood can be elavated in children with acute appendicitis. The aim of this research is to compare the diagnostic value of C-reactive protein from the blood and saliva of children with acute appendicitis and to prove wheter the analysis of biomarker from saliva as a minimally invasive procedure can be sufficient for diagnosis.

Detailed Description

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Conditions

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Acute Appendicitis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Patients with acute appendicitis

Patients with acute appendicitis, after surgery and with pathohistological confirmation

Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels

Intervention Type DIAGNOSTIC_TEST

Blood analysis of CRP and WBC levels Saliva analysis of CRP levels

Patients without acute appendicitis

Patients without acute appendicitis, after laboratory, clinical and/or radiological exclusion of acute admittance

Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels

Intervention Type DIAGNOSTIC_TEST

Blood analysis of CRP and WBC levels Saliva analysis of CRP levels

Interventions

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Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels

Blood analysis of CRP and WBC levels Saliva analysis of CRP levels

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* children with age from 5 to 17 with acute abdominal pain
* children with clinical signs of appendicitis

Exclusion Criteria

* previous diagnosis of chronic and/or malignant disease
* children wich had previous abdominal surgery
* pregnancy
Minimum Eligible Age

5 Years

Maximum Eligible Age

17 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital of Split

OTHER

Sponsor Role lead

Responsible Party

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Klaudio Pjer Milunovic

principal investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Zenon Pogorelić, PhD.Prof

Role: PRINCIPAL_INVESTIGATOR

University Hospital of Split

Central Contacts

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Klaudio Pjer MD Milunovic

Role: CONTACT

+38521556723

Other Identifiers

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CHCSplit

Identifier Type: -

Identifier Source: org_study_id

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