Comparison of Salivary Procalcitonin (PCT) Levels and Serum PCT Levels

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

160 participants

Study Classification

INTERVENTIONAL

Study Start Date

2024-06-01

Study Completion Date

2025-04-01

Brief Summary

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Recently, it has been seen that investigations from saliva samples could be an alternative to those from blood samples. Saliva collection is a simple, non-invasive, cost-effective, and relatively easy method, making it potentially suitable as a new diagnostic tool in pediatric patients. In the current literature, elevated levels of saliva CRP, TNF-α, IL-6, and IFN-γ have been reported in inflammatory conditions. However, while there are animal studies suggesting the use of saliva PCT levels for focal diseases such as gingival inflammation and periodontitis and as a potential tool for non-invasive detection of sepsis, there is no human study regarding its use in systemic infections.

The aim of this study is to evaluate the correlation between serum PCT levels and saliva PCT levels in children suspected of SBE and to determine the diagnostic value of saliva PCT.

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Detailed Description

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Conditions

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Bacterial Infections Children, Only Procalcitonin Saliva

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Patients selection

Children under 1 year of age will be recruited for saliva and blood sample collection in the study

Group Type OTHER

Sliva Procalcitonin

Intervention Type DIAGNOSTIC_TEST

Sliva Procalcitonin vs Blood procalcitonin

Interventions

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Sliva Procalcitonin

Sliva Procalcitonin vs Blood procalcitonin

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Being under one year of age
* Having serum Procalcitonin (PCT) requested due to suspicion of systemic infection

Exclusion Criteria

* Being over one year of age
* Having a chronic illness that could cause elevation in inflammatory biomarkers
* Taking any medication (such as antibiotics, immunomodulatory, or immunosuppressive drugs, etc.) that could affect inflammatory biomarkers
* Diagnosis of gingivostomatitis

Minimum Eligible Age

0 Years

Maximum Eligible Age

1 Year

Eligible Sex

ALL

Accepts Healthy Volunteers

No