Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
60 participants
OBSERVATIONAL
2022-01-02
2025-01-31
Brief Summary
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In this context, innovative strategies are necessary to identify new therapeutic targets and implement new treatments to overcome resistance phenomena in the clinic.
Objective: Our goal will be to generate tumoroids and stem-like cell lines (PDX) from patient tumor samples.
Methods: We will establish tumor tumoroids and stem cell lines from patient samples. These preclinical models will allow us to test a large number of drugs, quickly and efficiently thanks to models as close as possible to patient tumors and limiting the use of animal models (3R).
Overall, this project should enable major advances in the treatment of glioblastoma and brain metastases and enable the rapid testing of new molecules in clinical trials thanks to the homology of our models with our patients' diseases.
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Detailed Description
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Conditions
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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patients with primitive tumor
Patient samples will be collected during routine care neurosurgical resection.
Fresh tumor sampling
Patient samples will be collected during neurosurgical resection. .
patients with brain metastasis
Patient samples will be collected during routine care neurosurgical resection.
Fresh tumor sampling
Patient samples will be collected during neurosurgical resection. .
Interventions
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Fresh tumor sampling
Patient samples will be collected during neurosurgical resection. .
Eligibility Criteria
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Inclusion Criteria
* Brain tumor neuro-imaging
* Eligible for neurosurgery
Exclusion Criteria
18 Years
ALL
No
Sponsors
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Assistance Publique Hopitaux De Marseille
OTHER
Responsible Party
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Locations
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Assistance publique hopitaux de marseille
Marseille, , France
Countries
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Central Contacts
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Facility Contacts
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Emeline Tabouret
Role: primary
Other Identifiers
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RCAPHM20_0037 - HITCH
Identifier Type: -
Identifier Source: org_study_id
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