Evaluation of the Incidence of NTRK Gene Fusion in Adult Brain Tumours

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

140 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-10-31

Study Completion Date

2023-02-08

Brief Summary

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This is a retrospective, mono centric, exploratory study to assess the incidence of a genomic alteration: NTRK gene fusion, in adult gliomas and brain metastases.

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Detailed Description

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Retrospective mono centric study of medical data (clinical, histological, molecular and imaging) from medical records and analysis of available excisional tissue samples.

Conditions

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Glioma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Glioma

(20 grade II gliomas, 20 grade III gliomas and 20 glioblastomas)

Glioma data collection

Intervention Type OTHER

Glioma data collection

Brain metastasis

The "brain metastasis" cohort consists of 80 patients, including 30 patients for whom the matched primary tumour is available

Brain metastasis data collection

Intervention Type OTHER

Brain metastasis data collection

Interventions

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Glioma data collection

Intervention Type OTHER

Brain metastasis data collection

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adult male or female subject;
* Glioma or brain metastasis operated on in our institution, histologically confirmed (WHO classification 2016);
* Subject with a frozen tumour sample \< 5 years old;
* Subject for whom all clinico-radiological data are available;
* Subject affiliated to a health insurance scheme;
* Subject who has been informed of the research and who has not indicated his opposition to the use of his medical data and who has signed a consent for the use of his tumour sample.

Exclusion Criteria

* Patient under legal protection, guardianship or deprived of liberty by judicial or administrative decision
* Biological samples not available and/or in insufficient quantity for analysis

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No