Evaluate Aerobic Exercise on Myocardial Fibrosis and Intestinal Flora in Dilated Cardiomyopathy Diagnosed First Time.

NCT ID: NCT06039969

Last Updated: 2023-09-15

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2023-10-01
• Study Completion Date: 2025-10-01

Brief Summary

To invegstive the Changes of Intestinal Flora and the improvements of Cardiac Fibrosis in Patients With Dilated Cardiomyopathy Diagnosed for the First Time by heart Rehabilitation

Detailed Description

Previous studies have confirmed that Aerobic exercise rehabilitation can reduce the rate of readmission of patients with heart failure and improve their cardiopulmonary endurance and exercise ability. However, whether aerobic exercise rehabilitation can inhibit myocardial fibrosis or delay the progress of fibrosis in patients with heart failure has not been reported. At the same time, some studies have shown that the change of intestinal microbial flora may promote the progress of heart failure, and regular aerobic exercise will also lead to the change of intestinal microbial flora, but whether aerobic exercise rehabilitation can improve intestinal microbial flora in patients with dilated cardiomyopathy has not been reported. In our study, patients who were hospitalized for heart failure for the first time and were finally diagnosed with dilated cardiomyopathy were recruited. Recruited patients will enter the routine cardiac rehabilitation process and make an individualized aerobic exercise plan according to the cardiopulmonary exercise test. Cardiac MRI and intestinal microflora changes will be evaluated.

Conditions

Cardiac Rehabilitation; Myocardial Fibrosis

Study Design

• Observational Model Type: CASE_CROSSOVER
• Study Time Perspective: PROSPECTIVE

Study Groups

Cardiac MRI will be performed in patients with heart failure caused by cardiomyopathy.

Cardiac MRI will be performed in patients with heart failure caused by cardiomyopathy. At the same time Collect patient feces.this is a obvertional study ,ther is no intervetion

Intervention Type: OTHER

This is an obvertional study and there is no intervention

Interventions

This is an obvertional study and there is no intervention

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• 1、Patients hospitalized for the first time because of heart failure 2、The patient who was definitely diagnosed as dilated cardiomyopathy for the first time

Exclusion Criteria

• 1、Other types of cardiomyopathy 2、Has been diagnosed as dilated cardiomyopathy. 3、malignant tumor 4、acute infection 5、Cannot perform cardiopulmonary exercise test.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Nanjing Medical University

OTHER

Sponsor Role: lead

Responsible Party

Jin Geng

associate doctor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

XiWen Zhang, MD

Role: STUDY_DIRECTOR

Huai'an First People's Hospital

Locations

Huai'An First People'S Hospital

Huai'an, Jiangsu, China

Site Status: RECRUITING

Countries

China

Central Contacts

Jin Geng, MD

Role: CONTACT

gj885258@163.com

+86-17753124846

XiWen Zhang, MD

Role: CONTACT

Facility Contacts

Xiaozhong Yang, MD

Role: primary

Other Identifiers

20230911

Identifier Type: -

Identifier Source: org_study_id