Improving Pulmonary Hypertension Screening by Echocardiography
NCT ID: NCT06038149
Last Updated: 2025-11-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
200 participants
OBSERVATIONAL
2023-11-11
2026-02-28
Brief Summary
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Detailed Description
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Participants will be recruited from patients referred for the first time for transthoracic echocardiography at the Royal United Hospitals Bath National Health Service (NHS) Foundation Trust, Royal Free Hospital NHS Foundation Trust, Sheffield Teaching Hospitals, Royal Papworth Hospital, and Golden Jubilee Hospital.
The investigators will prospectively recruit patients without a diagnosis of Pulmonary Hypertension.
Transthoracic echocardiographic (TTE) imaging will be performed in line with British Society of Echocardiography minimum dataset guidelines, and comprehensive right heart echocardiographic imaging and analysis will be performed following the British Society of Echocardiography recommendations for assessing right heart function, in addition to the IMPULSE algorithm;
A right ventricular free wall longitudinal strain value of less than -23%, or, right ventricular fractional area change (FAC) less than 35% in females/30% in males, in addition to a right ventricular isovolumetric relaxation time in excess of 73ms in patients with low/Intermediate probability of PH by current guidelines would categorise that patient as being IMPULSE positive.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Low PH probability
Individuals identified as being of a low risk of pulmonary hypertension on routine echocardiography through existing British Society of Echocardiography/ European Society of Cardiology guidelines will undergo a research echocardiogram on the day of their planned right heart catheter.
Transthoracic echocardiogram
A painless ultrasound scan of the heart.
Intermediate PH probability
Individuals identified as being of an intermediate risk of pulmonary hypertension on routine echocardiography through existing British Society of Echocardiography/ European Society of Cardiology guidelines will undergo a research echocardiogram on the day of their planned right heart catheter.
Transthoracic echocardiogram
A painless ultrasound scan of the heart.
Interventions
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Transthoracic echocardiogram
A painless ultrasound scan of the heart.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Risk factors for Pulmonary arterial hypertension (PAH), chronic thromboembolic pulmonary hypertension (CTEPH)
* Unexplained elevation of B-type natriuretic peptide (BNP/proBNP)
* Referred for catheterisation.
Exclusion Criteria
* Known or suspected congenital heart disease
* Patients unlikely to benefit from management of PH or its underlying causes.
18 Years
ALL
Yes
Sponsors
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Janssen-Cilag Ltd.
INDUSTRY
Royal Free Hospital NHS Foundation Trust
OTHER
Sheffield Teaching Hospitals NHS Foundation Trust
OTHER
Royal Papworth Hospital
OTHER_GOV
Golden Jubilee National Hospital
OTHER_GOV
University of Bath
OTHER
Liverpool John Moores University
OTHER
Royal United Hospitals Bath NHS Foundation Trust
OTHER
Responsible Party
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Principal Investigators
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Daniel X Augustine, BSc(Hons)
Role: PRINCIPAL_INVESTIGATOR
Royal United Hospitall NHS Foundation Trust
Locations
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Royal United Hospital NHS Foundation Trust
Bath, Banes, United Kingdom
Golden Jubilee Hospital
Glasgow, Lanarkshire, United Kingdom
Sheffield Teaching Hospitals NHS Foundation Trust
Sheffield, South Yorkshire, United Kingdom
Royal Papworth Hospital
Cambridge, , United Kingdom
Royal Free NHS Foundation Trust
London, , United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Martin Johnson
Role: primary
Role: backup
Other Identifiers
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IMPULSE
Identifier Type: -
Identifier Source: org_study_id
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