Heart Failure-USB: Prediction and Progression

NCT ID: NCT04000061

Last Updated: 2025-04-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

6000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-06-13

Study Completion Date

2026-12-31

Brief Summary

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This retrospective cohort study is to identify triggers of heart failure (HF) development and drivers of HF progression as well as the underlying cardiac disease (phenotype) to identify patients at risk and predict the clinical course of the disease. Data of patients who were hospitalized during the years 2010-2023 with acute coronary syndrome (ACS) and/ or with acute heart failure (AHF) will be collected and analyzed. In a subgroup cohort efficacy and safety of digoxin in patients with acute heart failure triggered by tachyarrhythmia will be evaluated.

Detailed Description

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Conditions

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Acute Heart Failure Acute Coronary Syndrome Heart Failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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acute coronary syndrome (ACS)

Outcome information (all-cause death, heart failure (HF) hospitalizations) of patients hospitalized with a primary diagnosis of ACS is analyzed.

medical chart review

Intervention Type OTHER

data generated by medical review include Medical history, Medications at presentation, during hospitalization and at discharge, New York Heart Association (NYHA) class, Killip class, Electrocardiographic (ECG) data, echocardiographic data, Interventions (Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Graft (CABG), Implantable Cardioverter Defibrillator (ICD) implantation, Cardiac Resynchronization Therapy (CRT) Implantation), Outcome Information: all-cause death, HF hospitalizations

data generated by direct IT export

Intervention Type OTHER

data generated by direct IT export include Anthropometric data (age, sex, height, weight), Vital signs, Laboratory data

acute heart failure (AHF)

Outcome information (all-cause death, heart failure (HF) hospitalizations) of patients hospitalized with a primary or secondary diagnosis of AHF is analyzed.

medical chart review

Intervention Type OTHER

data generated by medical review include Medical history, Medications at presentation, during hospitalization and at discharge, New York Heart Association (NYHA) class, Killip class, Electrocardiographic (ECG) data, echocardiographic data, Interventions (Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Graft (CABG), Implantable Cardioverter Defibrillator (ICD) implantation, Cardiac Resynchronization Therapy (CRT) Implantation), Outcome Information: all-cause death, HF hospitalizations

data generated by direct IT export

Intervention Type OTHER

data generated by direct IT export include Anthropometric data (age, sex, height, weight), Vital signs, Laboratory data

Interventions

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medical chart review

data generated by medical review include Medical history, Medications at presentation, during hospitalization and at discharge, New York Heart Association (NYHA) class, Killip class, Electrocardiographic (ECG) data, echocardiographic data, Interventions (Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Graft (CABG), Implantable Cardioverter Defibrillator (ICD) implantation, Cardiac Resynchronization Therapy (CRT) Implantation), Outcome Information: all-cause death, HF hospitalizations

Intervention Type OTHER

data generated by direct IT export

data generated by direct IT export include Anthropometric data (age, sex, height, weight), Vital signs, Laboratory data

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Patients hospitalized with a primary diagnosis of ACS
* Patients hospitalized with a primary or secondary diagnosis of AHF

Exclusion Criteria

* Existence of a documented statement of the patient against the scientific use of clinical data
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Basel, Switzerland

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Christian Müller, Prof. Dr.

Role: PRINCIPAL_INVESTIGATOR

Cardiology University Hospital Basel

Locations

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Cardiology, University Hospital Basel

Basel, , Switzerland

Site Status RECRUITING

Countries

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Switzerland

Central Contacts

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Christian Müller, Prof. Dr.

Role: CONTACT

0041 6132 86 549

Fiona Nafaa, MD

Role: CONTACT

+41 61 32 87747

Facility Contacts

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Christian Mueller, Prof. Dr.

Role: primary

+41 61 32 86 549

Other Identifiers

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2019-00956; me19Mueller

Identifier Type: -

Identifier Source: org_study_id

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