Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
30 participants
OBSERVATIONAL
2023-04-03
2025-07-31
Brief Summary
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* To screen out the key biomarkers of pediatric appendicitis.
* What are the microbial differences in different parts of pediatric appendicitis patients.
Participants will detect feces using 16s ribosomal RiboNucleicAcid (16S rRNA) gene sequencing technology and differences of the fecal metabolites between healthy children and appendicitis children were analyzed using untargeted metabolomics based on Liquid chromatography-tandem mass spectrometry(LC-M S/MS) platform.Through the analysis of intestinal bacterial flora and metabolomics association and the differential analysis of intestinal bacterial flora in different parts of the case group, the key bacterial flora and metabolites were excavated.
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Detailed Description
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Differences in the intestinal flora of different parts of the case group: the intestinal flora of the case group in feces and rectum were detected by 16s ribosomal RiboNucleicAcid (16S rRNA) gene sequencing technology, and the intestinal flora of different parts were analyzed and compared.
Through the analysis of intestinal bacterial flora and metabolomics association and the differential analysis of intestinal bacterial flora in different parts of the case group, the key bacterial flora and metabolites were excavated.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Case group
Children with appendectomy for appendicitis
No interventions assigned to this group
Control group
Children with no digestive disease or medical history
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Children aged 1-14 years with non-digestive tract disease and no history of digestive tract disease
Exclusion Criteria
* Allergic to antibiotic therapy drugs
* Patients with long-term drug use causing microbial structure changes or intestinal flora disorders
* Patients with other congenital diseases such as Meckel's diverticulum, intestinal rotation and other malrotation
* With other systemic diseases, such as obvious upper respiratory tract infection or myocarditis
* Children with other digestive system diseases after auxiliary examination or surgical diagnosis
1 Year
14 Years
ALL
Yes
Sponsors
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HongyiQu
OTHER
Responsible Party
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HongyiQu
professor
Principal Investigators
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Qu
Role: STUDY_CHAIR
Shandong First Medical University
Locations
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The First Affiliated Hospital Of Shandong First Medcial Unversity
Jinan, Shandong, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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YXLL-KY-2023 （009）
Identifier Type: -
Identifier Source: org_study_id
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