Diastolic Function in Myotonic Dystrophy Type 1

NCT ID: NCT06029192

Last Updated: 2023-09-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-06-02

Study Completion Date

2023-11-01

Brief Summary

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Myotonic dystrophy type 1 (DM1) is a neuromuscular disorder in relation with an unstable expansion of CTG repeat. Patients with DM1 are at risk of arrhythmia and conduction disorders. Mortality are mainly related to respiratory failure and sudden death. Patients with DM1 may suffer from obesity, arterial hypertension, diabetes mellitus and sleep apnea. These comorbidities are classically associated with left ventricular diastolic dysfunction (DD) .

The investigators aim to assess the prevalence of left ventricular diastolic dysfunction in patients with myotonic dystrophy type 1 , the distribution of DD grading as well as the long-term prognosis of DM1 patients with a left ventricular diastolic dysfunction.

Detailed Description

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Conditions

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Diastolic Dysfunction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* patients with genetic proven myotonic dystrophy type 1
* who experienced a Doppler- Echocardiography including an assessment of the left ventricular diastolic function

Exclusion Criteria

* wall motion basal abnormalities
* significant valvular disease
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre d'Investigation Clinique et Technologique 805

OTHER

Sponsor Role lead

Responsible Party

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Abdallah FAYSSOIL

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Abdallah FAYSSOIL, MD PhD

Role: PRINCIPAL_INVESTIGATOR

CHU Raymond Poincare

Locations

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Hopital Raymond Poincare

Garches, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Abdallah FAYSSOIL, MD PhD

Role: CONTACT

+33147107778

Facility Contacts

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ABDALLAH FAYSSOIL, MDPhD

Role: primary

003347101411

Other Identifiers

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ECHO-DM1

Identifier Type: -

Identifier Source: org_study_id

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