Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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NOT_YET_RECRUITING
NA
14 participants
INTERVENTIONAL
2025-09-01
2028-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
SINGLE
Study Groups
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"tACS Sham, tACS 10Hz, tACS 20Hz" experimental order
1. tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns.
2. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns.
3. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.
tACS Sham
Sham tACS will applied to the brain through the scalp for 20 minutes.
tACS 10Hz
10Hz tACS will applied to the brain through the scalp for 20 minutes.
tACS 20Hz
20Hz tACS will applied to the brain through the scalp for 20 minutes.
"HD-tACS 20Hz, HD-tACS 10Hz, HD-tACS Sham" experimental order
1. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.
2. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns.
3. tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns.
tACS Sham
Sham tACS will applied to the brain through the scalp for 20 minutes.
tACS 10Hz
10Hz tACS will applied to the brain through the scalp for 20 minutes.
tACS 20Hz
20Hz tACS will applied to the brain through the scalp for 20 minutes.
"HD-tACS 10Hz, HD-tACS 20Hz, HD-tACS Sham" experimental order
1. tACS 10Hz is a 10Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp or 20 or 40 minutes to entrain neuronal activity into 10Hz frequency patterns.
2. tACS 20Hz is a 20Hz non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for 20 or 40 minutes to entrain neuronal activity into 20Hz frequency patterns.
3. tACS Sham is a temporary non-invasive electrical stimulation that applies a weak oscillatory current to the brain through the scalp for up to 30 second, it is not designed to entrain neuronal activity into any external regulatory frequency patterns.
tACS Sham
Sham tACS will applied to the brain through the scalp for 20 minutes.
tACS 10Hz
10Hz tACS will applied to the brain through the scalp for 20 minutes.
tACS 20Hz
20Hz tACS will applied to the brain through the scalp for 20 minutes.
Interventions
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tACS Sham
Sham tACS will applied to the brain through the scalp for 20 minutes.
tACS 10Hz
10Hz tACS will applied to the brain through the scalp for 20 minutes.
tACS 20Hz
20Hz tACS will applied to the brain through the scalp for 20 minutes.
Eligibility Criteria
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Inclusion Criteria
2. has chronic pain, \>3 months;
3. is between 18 to 75 years of age;
4. is stable on oral pain medications at least two weeks. Patients are allowed to continue their pain medications, i.e., no change in pain medications.
NOTE: we plan to begin the study with the spinal cord injury (SCI) subject population as a cohort first, then expand to other subject populations
Exclusion Criteria
2. have pain, but not neuropathic, e.g., from inflammation at the incision wound of the residual limb or neuroma;
3. have a pacemaker metal implants or supplemental oxygen;
4. have amputation in their arm(s);
5. fail to have a motor contraction in the arm muscles with TMS;
6. are not able to follow commands, or to give consent;
7. have asthma or other pulmonary disease;
8. are not medically stable;
9. have preexisting psychiatric disorders;
10. alcohol or drug abuse.
18 Years
75 Years
ALL
No
Sponsors
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The University of Texas Health Science Center, Houston
OTHER
Responsible Party
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Sheng Li
Professor
Principal Investigators
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Sheng Li, MD, Ph.D
Role: PRINCIPAL_INVESTIGATOR
The University of Texas Health Science Center, Houston
Locations
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The University of Texas Health Science Center
Houston, Texas, United States
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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HSC-MS-22-0046 (Experiment 2)
Identifier Type: -
Identifier Source: org_study_id
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