Blood Pressure and Obstructive Sleep Apnea

NCT ID: NCT06027424

Last Updated: 2023-09-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2037 participants

Study Classification

OBSERVATIONAL

Study Start Date

2022-10-26

Study Completion Date

2023-07-16

Brief Summary

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Bidirectional and causal relationship exists between obstructive sleep apnea (OSA) and hypertension in a dose-response manner, independent of confounding variables such as age, smoking, and body mass index. OSA is conventionally diagnosed and graded by apnea-hypopnea index (AHI). The relationship between AHI and changes of blood pressure deserves further investigation.

Detailed Description

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Approximately 50% of patients with obstructive sleep apnea (OSA) have hypertension; up to 30% of patients with hypertension have OSA, and the prevalence is even higher in those of resistant hypertension. OSA is conventionally diagnosed and graded by apnea-hypopnea index (AHI). This retrospective study aimed to determine if OSA severity and AHI have effect on blood pressure measurements and the nocturnal changes following an overnight sleep.

Conditions

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The Effects of Obstructive Sleep Apnea on Blood Pressure Measurement

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Non-OSA

AHI \< 5 events/h (AHI, apnea-hypopnea index, the number of apneas and hypopneas per hour of total sleep time)

Intervention Type OTHER

observational study, no intervention

Mild OSA

5 events/h ≤ AHI \< 15 events/h

Intervention Type OTHER

observational study, no intervention

Moderate OSA

15 events/h ≤ AHI \< 30 events/h

Intervention Type OTHER

observational study, no intervention

Severe OSA

AHI ≥ 30 events/h

Intervention Type OTHER

observational study, no intervention

Interventions

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observational study, no intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

(1). Individuals who underwent full-night polysomnography at Taipei VGH for symptoms related to obstructive sleep apnea, such as snoring and daytime somnolence; (2). Feasibility to measure BP via wrist monitors; (3). Confirmation of wakefulness through electroencephalography.

Exclusion Criteria

(1). Failure to measure BP via wrist monitors; (2). Age younger than 18 years; (3). Sleep efficiency less than 50%; (4). Central sleep apnea ≥ 50%
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Taipei Veterans General Hospital, Taiwan

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Taipei Veterans General Hospital

Taipei, , Taiwan

Site Status

Countries

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Taiwan

Other Identifiers

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2022-07-013CC

Identifier Type: -

Identifier Source: org_study_id

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