Effects of Different Continuous Renal Replacement Therapy Patterns on Ionized Calcium in Patients With Citrate Anticoagulants Using Calcium-containing Replacement Solutions
NCT ID: NCT06021080
Last Updated: 2025-08-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
30 participants
OBSERVATIONAL
2023-10-09
2026-12-09
Brief Summary
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This prospective, single-center, observational cohort study will screen all patients receiving CRRT for eligibility. General clinical information will be collected before commencing CRRT treatment. Patients will be randomly assigned to either the veno-venous hemofiltration (CVVH) or continuous veno-venous hemodialysis (CVVHD) group and switch to the alternative mode in the subsequent treatment session. Pre-filter and post-filter ionized calcium, systemic total and ionized calcium, and effluent total and ionized calcium will be measured 2 hours after the initiation of CRRT. Electrolyte levels, arterial blood gases, hourly citrate dose, and total citrate dose will be recorded every 6 hours until the end of CRRT. The primary outcome is the difference in ionized calcium concentrations at each site over time between the two modes.
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Detailed Description
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Conditions
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Study Design
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CASE_CROSSOVER
PROSPECTIVE
Study Groups
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CVVHD
Continuous Veno-Venous Hemosdialysis
CVVHD
CVVHD therapy
CVVH
Continuous Veno-Venous Hemofiltration
CVVH
CVVH therapy
Interventions
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CVVH
CVVH therapy
CVVHD
CVVHD therapy
Eligibility Criteria
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Inclusion Criteria
2. Receiving citrate anticoagulation;
3. Obtain Informed consent from patients or next of kin.
Exclusion Criteria
2. Allergic to citrate anticoagulants;
3. Severe liver dysfunction (total bilirubin levels exceeding two times the normal range);
4. Hypoxemia (PaO2 \< 60 mmHg);
5. Inadequate tissue perfusion (blood pressure \< 90/60 mmHg despite high doses of vasoactive agents);
6. Hyperlactatemia (lactate\> 4 mmol/L);
7. Hypernatremia;
8. Estimated length of hospital stay \< 48h;
9. Participated in other studies.
18 Years
100 Years
ALL
No
Sponsors
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Fujian Provincial Hospital
OTHER
Responsible Party
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Han Chen
Deputy chief physician
Principal Investigators
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Han Chen, Ph.D., M.D.
Role: PRINCIPAL_INVESTIGATOR
Fujian Provincial Hospital
Locations
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Fujian Provincial Hospital
Fuzhou, Fujian, China
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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HChen
Identifier Type: -
Identifier Source: org_study_id
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