Predictive Value of Epicardial Adipose Tissue for Pulmonary Embolism and Death in Patients With Lung Cancer

NCT ID: NCT06017271

Last Updated: 2024-07-22

Basic Information

• Recruitment Status: WITHDRAWN
• Study Classification: OBSERVATIONAL
• Study Start Date: 2024-05-01
• Study Completion Date: 2024-07-19

Brief Summary

The occurrence and progression of lung cancer is related to visceral adipose tissue (VAT). Epicardial adipose tissue (EAT) is a kind of VAT, producing a variety of inflammatory cytokines and adipokines, participating in the formation of local inflammation, promoting the formation of pre-thrombotic state, and leading to the occurrence of thromboembolism. Patients with lung cancer have increased inflammatory response and are more prone to suffer thrombosis. However, in lung cancer patients, the clinical correlation between EAT and pulmonary embolism has not been reported. Objective: To analyze the risk factors of poor prognosis in lung cancer patients with PE, and to explore the predictive value of EAT in pulmonary embolism events and death in lung cancer patients. Methods: EAT volume and density, as well as anthropometric and blood biomarkers, were evaluated in a sample of lung cancer patients, half with pulmonary embolism and half without. The incidence of adverse prognosis and related factors were followed up by telephone.

Conditions

Pulmonary Embolism; Lung Cancer

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Study Groups

PE group

The CTPA diagnosis suggest pulmonary embolism

CTPA (computed tomography pulmonary angiography)

Intervention Type: DIAGNOSTIC_TEST

The CTPA diagnosis suggest or did not suggest pulmonary embolism.

control group

The CTPA diagnosis did not suggest pulmonary embolism

CTPA (computed tomography pulmonary angiography)

Intervention Type: DIAGNOSTIC_TEST

The CTPA diagnosis suggest or did not suggest pulmonary embolism.

Interventions

CTPA (computed tomography pulmonary angiography)

The CTPA diagnosis suggest or did not suggest pulmonary embolism.

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• The pathological diagnosis was lung cancer
• Pulmonary artery was evaluated by CTA during hospitalization.

Exclusion Criteria

• Patients with incomplete clinical data
• Patients with no follow-up data
• Patients with a history of PE before diagnosis of lung cancer

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

First Affiliated Hospital Xi'an Jiaotong University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Yang Yan

Role: STUDY_DIRECTOR

First Affiliated Hospital Xi'an Jiaotong University

Haichen Wang

Role: PRINCIPAL_INVESTIGATOR

First Affiliated Hospital Xi'an Jiaotong University

Locations

First Affiliated Hospital of Xian Jiaotong University

Xi'an, Shaanxi, China

Countries

China

Other Identifiers

XJTU1AF2023LSK-269

Identifier Type: -

Identifier Source: org_study_id