Aging Well Through Interactions and Scientific Education - Action Plan (AgeWISE-AP)
NCT ID: NCT06006962
Last Updated: 2025-11-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
128 participants
INTERVENTIONAL
2024-01-01
2027-12-31
Brief Summary
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Detailed Description
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AIM 1 (primary): To determine whether AgeWISE-AP increases older Veterans' engagement in lifestyle factors that promote brain health. AgeWISE provides information about the differences between normal and diseased brain aging and lifestyle factors that contribute to brain health. The action plan (AP) component will use this foundation to collaboratively create an individualized brain health plan to increase Veteran engagement in brain healthy lifestyle activities. H1. AgeWISE-AP participants will demonstrate increased engagement in brain-healthy lifestyle activities compared to the control group.
AIM 2 (primary): To determine whether AgeWISE-AP improves psychological wellness. AgeWISE provides information about the relationship between cognitive aging and affective states (e.g., depression) and attitudes about aging, and teaches stress reduction techniques. The action plan (AP) will provide additional individualized supports to improve psychological well-being with personalized goals and lifestyle modifications (e.g., diet, exercise, sleep, cognitive stimulation). H2. AgeWISE-AP participants will show increases in perception of control over cognitive aging, meaning and purpose in life, quality of life, and self-efficacy, as well as improved attitudes toward aging and decreased loneliness, depression, and anxiety compared to the control group.
AIM 3 (primary): To determine whether AgeWISE-AP improves cognition. Cognitive strategies to improve cognition and functioning are presented and practiced over three AgeWISE sessions, with homework to improve generalization to day-to-day life. Engagement in brain-healthy lifestyle activities will be accomplished through the action plan (AP). H3. Self-reported memory contentment, ability, and compensatory strategy use will increase and objective cognitive testing will be better for AgeWISE-AP participants compared to the control group.
Aim 4 (exploratory): To determine whether AgeWISE-AP influences biomarkers of brain health using structural neuroimaging methods. H4. At one-year follow-up AgeWISE-AP participants will have less volumetric decline in dementia-related brain regions compared to the control group.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Intervention
Receiving intervention - AgeWISE-AP
Aging Well through Interactions and Scientific Education - Action Plan
20-week program designed to provide education and individualized planning with a goal of improving brain health.
Waitlist Control
No intervention; will be invited to participate in intervention after completion of study.
No interventions assigned to this group
Interventions
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Aging Well through Interactions and Scientific Education - Action Plan
20-week program designed to provide education and individualized planning with a goal of improving brain health.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* English speaking as all intervention materials are written in English
Exclusion Criteria
* Active alcohol or substance abuse
60 Years
ALL
Yes
Sponsors
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VA Boston Healthcare System
FED
VA Office of Research and Development
FED
Responsible Party
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Principal Investigators
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Maureen O'Connor, PsyD
Role: PRINCIPAL_INVESTIGATOR
VA Bedford HealthCare System, Bedford, MA
Locations
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VA Bedford HealthCare System, Bedford, MA
Bedford, Massachusetts, United States
Countries
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Central Contacts
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Facility Contacts
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Andrew H Nguyen, MA
Role: primary
Other Identifiers
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E4828-R
Identifier Type: -
Identifier Source: org_study_id