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NCT06002828

Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors

Last Updated: 2025-11-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

2000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2023-10-13

Study Completion Date

2030-02-01

Brief Summary

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This study examines the impact of social and genetic factors on outcomes in adolescent and young adult (AYA) cancer survivors of Hodgkin or non-Hodgkin lymphoma. Compared to both older adult and childhood cancer patients, AYAs with cancer experience different diagnoses and specific biological, clinical, psychological and social factors that affect their risks for post-treatment morbidity and premature death. Collecting samples of blood samples and health and treatment information from cancer survivors of Hodgkin or non-Hodgkin lymphoma may help doctors identify conditions that increase the likelihood of AYAs getting sick and dying after treatment of cancer and better understand how to address the needs of adolescent and young adult cancer survivors.

Detailed Description

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PRIMARY OBJECTIVE:

I. To establish the association of social-environmental risk factors on both disease-free survival (DFS) and overall survival (OS) for adolescent and young adult cancer survivors.

SECONDARY OBJECTIVES:

I. To establish the associations of individual resilience factors on DFS and OS for adolescent and young adult cancer survivors.

II. To establish the associations of social-environmental risk factors and individual resilience factors on quality of life (QOL) for adolescent and young adult cancer survivors.

III. To quantify the extent to which alterations in human gene expression could potentially mediate the effects of social-environmental risk factors and individual resilience factors on DFS, and OS for adolescent and young adult cancer survivors.

EXPLORATORY OBJECTIVE:

I. To determine whether the relationship between social-environmental risk factors or individual resilience factors and distal outcomes may be moderated by race/ethnicity, sex and gender identity, and geography for adolescent and young adult cancer survivors.

OUTLINE: This is an observational study.

Participants complete questionnaires about health-related quality of life and undergo collection of blood samples at baseline and 6, 12, 18, and 24 months.

Conditions

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Hodgkin Lymphoma Non-Hodgkin Lymphoma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Observational (questionnaires, biospecimen collection)

Participants complete questionnaires about health-related quality of life and undergo collection of blood samples at baseline and 6, 12, 18, and 24 months.

Biospecimen Collection

Intervention Type PROCEDURE

Undergo collection of blood samples

Quality-of-Life Assessment

Intervention Type OTHER

Complete questionnaires

Questionnaire Administration

Intervention Type OTHER

Complete questionnaires

Interventions

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Biospecimen Collection

Undergo collection of blood samples

Intervention Type PROCEDURE

Quality-of-Life Assessment

Complete questionnaires

Intervention Type OTHER

Questionnaire Administration

Complete questionnaires

Intervention Type OTHER

Other Intervention Names

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Biological Sample Collection Biospecimen Collected Specimen Collection Quality of Life Assessment

Eligibility Criteria

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Inclusion Criteria

* Patient must be \>= 18 years of age at the time of registration
* Patient must have been between the ages of 15-39 at the time of their first primary cancer diagnosis of Hodgkin lymphoma or non-Hodgkin lymphoma (NHL)
* Patient must have completed therapy (with a complete response, per clinician determination) at the time of registration
* Patients last date of prior systemic therapy for first primary diagnosis for Hodgkin lymphoma or non-Hodgkin lymphoma must have been within one year prior to registration

* NOTE: Systemic therapy refers to all anti-cancer therapy, including but not limited to chemotherapy, intravenous (IV) or oral targeted medications, or radiation, and administered via a clinical trial or standard approach
* Patient must have an Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-3
* Patient must be English speaking in order to be able to complete the required QOL forms on this study

* NOTE: Sites cannot translate the associated QOL forms
* Patient must not be receiving active therapy for Hodgkin lymphoma or non-Hodgkin lymphoma
* Patient must have internet access through computer, tablet, or smartphone
* Patient must have email address
* Patient must have the ability to understand and the willingness to sign a written informed consent document. Patients with impaired decision-making capacity (IDMC) who have a legally authorized representative (LAR) or caregiver and/or family member available will also be considered eligible

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bradley J Zebrack

Role: PRINCIPAL_INVESTIGATOR

ECOG-ACRIN Cancer Research Group

EAQ211

Identifier Type: OTHER

Identifier Source: secondary_id

ECOG-ACRIN-EAQ211

Identifier Type: OTHER

Identifier Source: secondary_id

ECOG-ACRIN-EAQ211

Identifier Type: OTHER

Identifier Source: secondary_id

UG1CA189828

Identifier Type: NIH

Identifier Source: secondary_id

View Link

EAQ211

Identifier Type: -

Identifier Source: org_study_id

Evaluating the Impact of Social and Genetic Factors on Outcomes in Adolescent and Young Adult Cancer Survivors

Study Results

Basic Information

Brief Summary

Detailed Description

Conditions

Study Design

Study Groups

Observational (questionnaires, biospecimen collection)

Biospecimen Collection

Quality-of-Life Assessment

Questionnaire Administration

Interventions

Biospecimen Collection

Quality-of-Life Assessment

Questionnaire Administration

Other Intervention Names

Eligibility Criteria

Inclusion Criteria

Sponsors

National Cancer Institute (NCI)

ECOG-ACRIN Cancer Research Group

Responsible Party

Principal Investigators

Bradley J Zebrack

Locations

Anchorage Associates in Radiation Medicine

Anchorage Radiation Therapy Center

Alaska Breast Care and Surgery LLC

Alaska Oncology and Hematology LLC

Alaska Women's Cancer Care

Anchorage Oncology Centre

Katmai Oncology Group

Providence Alaska Medical Center

Fairbanks Memorial Hospital

Kingman Regional Medical Center

Mercy Hospital Fort Smith

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro

CARTI Cancer Center

PCR Oncology

Providence Saint Joseph Medical Center/Disney Family Cancer Center

Epic Care-Dublin

Bay Area Breast Surgeons Inc

Epic Care Partners in Cancer Care

Contra Costa Regional Medical Center

Providence Queen of The Valley

Bay Area Tumor Institute

Stanford Cancer Institute Palo Alto

Providence Medical Foundation - Santa Rosa

Providence Santa Rosa Memorial Hospital

Epic Care Cyberknife Center

BASS Medical Group - Lennon

Rocky Mountain Cancer Centers-Aurora

Boulder Community Foothills Hospital

Rocky Mountain Cancer Centers-Boulder

Rocky Mountain Cancer Centers - Centennial

The Women's Imaging Center

Colorado Blood Cancer Institute

Presbyterian - Saint Lukes Medical Center - Health One

Rocky Mountain Cancer Centers-Midtown

Rocky Mountain Cancer Centers-Rose

Rose Medical Center

Mountain Blue Cancer Care Center - Swedish

Rocky Mountain Cancer Centers - Swedish

Swedish Medical Center

The Melanoma and Skin Cancer Institute

Rocky Mountain Cancer Centers-Lakewood

Rocky Mountain Cancer Centers-Littleton

Rocky Mountain Cancer Centers-Sky Ridge

Rocky Mountain Cancer Centers-Longmont

Rocky Mountain Cancer Centers-Thornton

Holy Cross Hospital

Golisano Children's Hospital of Southwest Florida

Saint Luke's Cancer Institute - Boise

Saint Luke's Cancer Institute - Fruitland

Saint Luke's Cancer Institute - Meridian

Saint Luke's Cancer Institute - Nampa

Saint Luke's Cancer Institute - Twin Falls

Saint Anthony's Health

Rush - Copley Medical Center