Safety and Performance of the Hexanium TLIF System in the Treatment of Degenerative Disc Disease

NCT ID: NCT05997121

Last Updated: 2023-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

187 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-09

Study Completion Date

2027-10-30

Brief Summary

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The goal of this observational study is to confirm the safety and efficacy of the Hexanium TLIF system in the treatment of skeletally mature patients suffering from degenerative disc disease (disease that occurs when the spinal disk break down).

Part of their standard of care, participants will be questioned on their back and leg pains, their disability and if they have encountered any adverse effects since the Hexanium TLIF system implant surgery. Those data will be collected up to twenty four (24) months after the Hexanium TLIF system implant surgery.

Detailed Description

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The Hexanium TLIF study is a multicentric, international, ambispective, post market clinical follow-up study. This means that either subjects already implanted with the Hexanium TLIF system (retrospective subjects) or subjects planned for treatment with the Hexanium TLIF (prospective subjects) can be enrolled in the study.

Standard of care subjects data up to twenty four (24) months post Hexanium TLIF system implant procedure will be collected; key data include back and leg Visual Analogue Score (VAS), Oswestry Disability Index (ODI) score, and adverse events.

Data will be collected at Month 2, Month 6, Month 12 and Month 24 post surgery.

Conditions

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Intervertebral Disc Degeneration

Study Design

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Observational Model Type

COHORT

Study Time Perspective

OTHER

Interventions

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Transforaminal lumbar interbody fusion

Transforaminal Lumbar Interbody Fusion indicates a surgical approach in the lumbar spine to fuse the discal space between two vertebrae. These are joined by removing the disc and placing a cage in its place to restore the vertebral height. Screws and rods are also added to maintain the level secure while the bones fuse together.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient planned for Hexanium TLIF system implant or patient implant with Hexanium TLIF system (not prior to July 2021)
* Patient of 18 years old or more
* Patient has provided signed informed consent, or did not oppose to his/her data collection, per local regulation

Exclusion Criteria

* Infection, local to the operative site
* Signed of local inflammation
* Fever or leukocytosis
* Morbid obesity
* Pregnancy
* Paediatric cases, or patient still having general skeletal growth
* Spondylolisthesis unable to be reduced to Grade I
* Suspected or documented allergy or intolerance to metal
* Any case where the implant components selected for use would be too large or too small to achieve a successful result
* Any patient having inadequate tissue coverage over the operative site or inadequate bone stock or quality
* Any patient in which implant utilization would interfere with anatomical structures or expected physiological performance
* Prior fusion at the level to be treated
* Any case not needing a bone graft or fusion
* Any abnormality present which affects the normal process of bone remodelling including, but not limited to severe osteoporosis involving spine, bone absorption, osteopenia, primary or metastasis tumours involving the spine, active infection at the site or certain metabolic disorders affecting osteogenesis
* Any other condition which would preclude the potential benefit of spinal implant surgery, such as the presence of tumours or congenital abnormalities, fracture local to operating site, elevation of segmentation rate unexplained by other diseases, elevation of white blood count (WBC), or marked left shift in the WBC differential count
* Mental illness
* Any patient unwilling to cooperate with post-operative instructions
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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EVAMED

OTHER

Sponsor Role collaborator

SPINEVISION SAS

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Noel Graziani, Professor

Role: PRINCIPAL_INVESTIGATOR

Hopital Privé Clairval

Locations

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Clinique du dos Terrefort

Bruges, , France

Site Status RECRUITING

Clinique Saint Charles

Lyon, , France

Site Status RECRUITING

Hopital privé Clairval

Marseille, , France

Site Status RECRUITING

CHRU Nancy

Nancy, , France

Site Status RECRUITING

Polyclinique Majorelle

Nancy, , France

Site Status RECRUITING

Clinicque Générale Beaulieu

Geneva, , Switzerland

Site Status NOT_YET_RECRUITING

Countries

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France Switzerland

Central Contacts

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Renaud Duchenes

Role: CONTACT

+33 6 86 16 61 91

Hanta Ranaivoson

Role: CONTACT

Facility Contacts

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Ibrahim Obeid, Doctor

Role: primary

Emmanuel Favreul, Doctor

Role: primary

Noel Graziani, Professor

Role: primary

Nacer Mansouri, Doctor

Role: primary

Aurélie Toquart, Doctor

Role: primary

Frédéric Schils, Doctor

Role: primary

Other Identifiers

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SV005

Identifier Type: -

Identifier Source: org_study_id

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